Synchronous visual analysis and editing of RNA sequence and secondary structure alignments using 4SALE.
Synchronous visual analysis and editing of RNA sequence and secondary structure alignments using 4SALE.
复制标题
使用4sale的RNA序列和二级结构比对的同步视觉分析和编辑。
DOI：
10.1186/1756-0500-1-91
复制
发表时间：
2008-10-14
影响因子：
1.8
通讯作者：
Wolf M
中科院分区：
文献类型：
--
作者：
Seibel PN;Müller T;Dandekar T;Wolf M
非编码RNA序列的功能主要由其二级结构决定，因此非编码RNA序列家族在结构水平上比在序列水平上保守得多。了解非编码 RNA 序列家族的功能需要两件事：手工制作或手工改进的比对以及二级结构的详细分析。有多种工具可以帮助执行这些任务，但所有这些工具都是专门的，并且只专注于一个方面，即编辑对齐或绘制二级结构。问题是这两项任务需要同时执行。 4SALE旨在同步处理RNA的序列和二级结构信息。通过包含同步可视化和编辑 RNA 序列和二级结构信息的全新方法，4SALE 能够更轻松地改进和理解 RNA 序列和二级结构进化。 4SALE 是同时处理 RNA 序列和二级结构信息的又一步。它提供了一种全新的方式来视觉监控不同的结构方面，同时编辑路线。该软件可从其网站免费获取和分发：
The function of a noncoding RNA sequence is mainly determined by its secondary structure and therefore a family of noncoding RNA sequences is much more conserved on the structural level than on the sequence level. Understanding the function of noncoding RNA sequence families requires two things: a hand-crafted or hand-improved alignment and detailed analyses of the secondary structures. There are several tools available that help performing these tasks, but all of them are specialized and focus on only one aspect, editing the alignment or plotting the secondary structure. The problem is both these tasks need to be performed simultaneously. 4SALE is designed to handle sequence and secondary structure information of RNAs synchronously. By including a complete new method of simultaneous visualization and editing RNA sequences and secondary structure information, 4SALE enables to improve and understand RNA sequence and secondary structure evolution much more easily. 4SALE is a step further for simultaneously handling RNA sequence and secondary structure information. It provides a complete new way of visual monitoring different structural aspects, while editing the alignment. The software is freely available and distributed from its website at