Hypocholesterolemia as a predictor of death: a prospective study of 224 nursing home residents.
Hypocholesterolemia as a predictor of death: a prospective study of 224 nursing home residents.
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低胆固醇血症作为死亡的预测因子：一项针对 224 名疗养院居民的前瞻性研究。
DOI：
10.1093/geronj/46.3.m84
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Goldberg,AP
中科院分区：
文献类型：
--
作者：
Verdery,RB;Goldberg,AP
研究了所有养老院居民的胆固醇、白蛋白、血红蛋白和葡萄糖水平以及人体测量变量与死亡风险的关系。死亡风险与胆固醇水平呈“u形”函数关系。胆固醇≤3.4 mmol / l者相对风险增加10倍，最低风险与胆固醇水平（4.0-5.0 mmol / l）的中等生育水平相关。对于任何水平的血浆胆固醇，风险至少在6个月内保持不变。低白蛋白、低血红蛋白和高空腹血糖水平也与死亡率增加有关；胆固醇水平与这些危险因素的水平呈非线性相关。比例风险模型显示，不活动、至少II期褥疮的存在以及肠内喂养也是死亡的危险因素。由于低胆固醇血症与褥疮、白细胞计数升高和肠内喂养的存在显著相关（p< 0.05），因此低胆固醇血症与死亡风险之间的关联很可能是由于其与营养不良和感染有关
The relationship of cholesterol, albumin, hemoglobin and glucose levels, and anthropometric variables to risk of death was examined in all residents of a nursing home. Risk of death was a “u-shaped” function of the cholesterol levels. A tenfold increase in relative risk was associated with cholesterol ≤ 3.4 mmolll, and the least risk was associated with the middle fertile of cholesterol levels (4.0–5.0 mmolll). For any level of plasma cholesterol, risk was constant with time for at least 6 months. Low albumin, low hemoglobin, and high fasting glucose levels were also associated with increased mortality; cholesterol levels were nonlinearly related to levels of these risk factors. Proportional hazards models showed that immobility, presence of decubitus ulcers of at least stage II, and use of enteral feeding were also risk factors for death. Because hypocholesterolemia correlated significantly (p< .05) with the presence of decubiti, elevated white blood cell count, and use of enteral feeding, the association between hypocholesterolemia and risk of death was most likely due to its association with malnutrition and infection