Alzheimer II astrocytosis following methionine sulfoximine.
Alzheimer II astrocytosis following methionine sulfoximine.
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甲硫氨酸亚磺酰亚胺后阿尔茨海默氏 II 型星形细胞增多症。
DOI：
10.1001/archneur.1975.00490440073012
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发表时间：
1975
影响因子：
--
通讯作者：
M. Norenberg
中科院分区：
文献类型：
--
作者：
J. A. Gutierrez;M. Norenberg
在成年大鼠给药蛋氨酸亚砜亚胺（MSO）后的发作前期进行了光镜研究。主要的形态学观察是阿尔茨海默氏II型星形胶质细胞在灰质中的发展，这表明MSO诱导的代谢异常最初仅限于星形胶质细胞。鉴于Aizheimer II型星形胶质细胞与高氨血症状态的相关性，药物毒性可能继发于氨的存在。一个可能的机制涉及星形胶质细胞在MSO产生的癫痫发作的发展。
A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Aizheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.