Human Papillomavirus Type Distribution in Invasive Cervical Cancer and High-Grade Cervical Intraepithelial Neoplasia Across 5 Countries in Asia
Human Papillomavirus Type Distribution in Invasive Cervical Cancer and High-Grade Cervical Intraepithelial Neoplasia Across 5 Countries in Asia
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DOI：
10.1097/igc.0b013e31827670fd
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Chen, Jing
中科院分区：
文献类型：
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作者：
Quek, Swee Chong;Lim, Boon Kiong;Chen, Jing
目的：在马来西亚、越南、新加坡、韩国和菲律宾这5个亚洲国家进行了独立的、前瞻性的、多中心的、以医院为基础的横断面研究。这些研究的目的是评估浸润性宫颈癌(ICC)和高度癌前病变的妇女中人乳头状瘤病毒(HPV)类型(高危型和其他类型包括混合感染)的患病率。方法：选择21岁以上经组织学诊断为宫颈浸润性癌和宫颈上皮内瘤变[CIN 2或3和原位腺癌(AIS)]的妇女。组织病理学家复习宫颈标本以确定ICC或CIN2/3/AIS病变的存在，并用短片段(10)-DNA酶免疫分析-线探针检测14种致癌HPV型和11种非致癌HPV型。结果：在上述5个亚洲国家中，有500例确诊为ICC[鳞状细胞癌(SCC)、腺癌/腺鳞癌(ADC/ASC)]和CIN2/3/AIS。在确诊的ICC病例中，93.8%-97.0%(菲律宾为84.5%)检出人乳头瘤病毒DNA[鳞癌94.0%-98.7%；HPV16(36.8%~61.3%)、HPV18(12.9%~35.4%)、HPV52(5.4%~10.3%)、HPV45(1.5%~17.2%)。HPV16型(29.7%~46.6%)是最常见的HPV型，其次是HPV52型(17.0%~66.7%)和HPV58型(8.6%~16.0%)。这些数据对公共卫生当局评估现有和未来的宫颈癌预防策略具有重要意义，包括在这些亚洲人群中进行基于BPV-DNA检测的筛查和HPV疫苗接种。
Objective: Independent, prospective, multicenter, hospital-based cross-sectional studies were conducted across 5 countries in Asia, namely, Malaysia, Vietnam, Singapore, South Korea, and the Philippines. The objectives of these studies were to evaluate the prevalence of human papillomavirus (HPV) types (high risk and others including coinfections) in women with invasive cervical cancer (ICC) and high-grade precancerous lesions.Methods: Women older than 21 years with a histologic diagnosis of ICC and cervical intraepithelial neoplasia [CIN 2 or 3 and adenocarcinoma in situ (AIS)] were enrolled. Cervical specimens were reviewed by histopathologists to confirm the presence of ICC or CIN 2/3/AIS lesion and tested with short PCR fragment(10)-DNA enzyme immunoassay-line probe assay for 14 oncogenic HPV types and 11 non-oncogenic HPV types. The prevalence of HPV 16, HPV 18, and other high-risk HPV types in ICC [including squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (ADC/ASC)] and ClN 2/3/AIS was estimated.Results: In the 5 Asian countries, diagnosis of ICC was confirmed in 500 women [SCC (n = 392) and ADC/ASC (n = 108)], and CIN 2/3/AIS, in 411 women. Human papillomavirus DNAwas detected in 93.8% to 97.0% (84.5% for the Philippines) of confirmed ICC cases [94.0%-98.7% of SCC; 87.0%-94.3% (50.0% for the Philippines) of ADC/ASC] and in 93.7% to 100.0% of CLN 2/3/MS. The most common types observed among ICC cases were HPV 16 (36.8%-61.3%), HPV 18 (12.9%-35.4%), HPV 52 (5.4%-10.3%), and HPV 45 (1.5%-17.2%), whereas among ON 2/3/MS cases, HPV 16 (29.7%-46.6%) was the most commonly observed type followed by HPV 52 (17.0%-66.7%) and HPV 58 (8.6%-16.0%).Conclusions: This article presents the data on the HPV prevalence, HPV type distribution, and their role in cervical carcinogenesis in 5 Asian countries. These data are of relevance to public health authorities for evaluating the existing and future cervical cancer prevention strategies including BPV-DNA testing based screening and HPV vaccination in these Asian populations.