The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
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DNA疫苗与左旋咪唑佐剂免疫小鼠对日本血吸虫感染的保护作用
DOI：
10.1016/j.vaccine.2008.01.056
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发表时间：
2008-03-28
期刊：
影响因子：
5.5
通讯作者：
Wang, Bin
中科院分区：
文献类型：
--
作者：
Wang, Xiao;Jin, Huali;Wang, Bin
左旋咪唑（LMS）作为佐剂可增强DNA疫苗接种中的细胞介导免疫;我们在小鼠攻击模型中研究了LMS制剂中DNA疫苗VR 1012-SjGST-32的功效和肝脏免疫病理学缓解。与对照组相比，VR 1012-SjGST-32联合LMS能显著降低虫卵负荷，并能显著降低与肝脏慢性炎症相关的免疫病理学并发症，这与Th 1型应答明显相关。总之，这些结果表明，LMS作为一个潜在的血吸虫DNA疫苗佐剂，可以提高蠕虫杀死和疾病预防，这可能是通过诱导免疫小鼠中的一个强大的Th 1-显性环境介导的。(C)2008爱思唯尔有限公司保留所有权利。
Levamisole (LMS) as an adjuvant enhances cell-mediated immunity in DNA vaccination; we investigated the efficacy and liver immunopathology alleviation of a DNA vaccine, VR1012-SjGST-32, in a LMS formulation in the murine challenge model. Compared to controls, the VR1012-SjGST-32 plus LMS can reduce worm and egg burdens, as welt as, immunopathological complications associated chronic inflammation significantly in liver, which were apparently associated with Th1-type response. Together, these results suggest that the LMS as a potential Schistosome DNA vaccine adjuvant can enhance both worm killing and disease prevention, which is possibly mediated through the induction of a strong Th1-dominant environment in immunized mice. (C) 2008 Elsevier Ltd. All rights reserved.