Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069
Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069
复制标题
DOI：
10.1002/cbdv.202100674
复制
发表时间：
2021-10-27
影响因子：
2.9
通讯作者：
Capon, Robert J.
中科院分区：
文献类型：
--
作者：
Song, Fuhang;Yang, Na;Capon, Robert J.
对从南海沉积物中分离的链霉菌MS180069进行化学分析，发现新的苯并[f]异吲哚-二酮生物碱bhimamycin J(1)。结构通过广泛的光谱分析确定，包括HRMS， 1D， 2D NMR和x射线衍射技术。一项分子对接研究发现，1是一个与人血管紧张素转换酶2 （ACE2）结合的新分子基序，ACE2最近被描述为负责吸收2019-CoV-2的细胞表面受体。酶分析证实1在25 μ g/mL时对ACE2的抑制率为79.7%。
Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 mu g/mL.