Metal-catalysed halogen exchange reactions of aryl halides
Metal-catalysed halogen exchange reactions of aryl halides
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DOI：
10.1039/b818155a
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Sheppard, Tom D.
中科院分区：
文献类型：
--
作者：
Sheppard, Tom D.
芳基卤本身是常见的合成目标，也是高度通用的合成中间体。芳基氯比其他卤化物衍生物更广泛地获得并且更容易合成，因此开发用于互变芳基卤化物衍生物的有效方法将是非常有用的。本文概述了哪些转化是特别理想的，并介绍了在开发使用铜、镍或钯催化剂进行这些转化的方法方面取得的进展。这些反应的可能机制进行了讨论，以确定未来的调查领域。
Aryl halides are common synthetic targets themselves, and also highly versatile synthetic intermediates. Aryl chlorides are much more widely available and easier to synthesise than the other halide derivatives, so the development of effective methods for interconverting aryl halide derivatives would therefore be extremely useful. This article outlines which transformations are particularly desirable, and describes the progress that has been made on developing methods for carrying out those transformations using copper, nickel or palladium catalysts. The possible mechanisms of these reactions are discussed, with a view to identifying areas for future investigation.