Analysis of immunoglobulin G-binding-protein expression by invasive isolates of Streptococcus pyogenes.
Analysis of immunoglobulin G-binding-protein expression by invasive isolates of Streptococcus pyogenes.
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分析化脓性链球菌侵袭性分离株的免疫球蛋白 G 结合蛋白表达。
DOI：
10.1128/cdli.2.4.484-486.1995
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Boyle,MD
中科院分区：
文献类型：
--
作者：
Raeder,R;Boyle,MD
作为疾病控制和预防中心监测研究的一部分收集的侵袭性A组链球菌分离株进行了免疫球蛋白G （IgG）结合蛋白表达分析。鉴定了A组M1血清型分离株的两种igg结合表型。第一组表达一种表面蛋白，结合所有四种人IgG亚类（IIo型），并被兔抗血清m1特异性抗血清识别，而不被正常兔血清识别。第二组表达一种igg结合蛋白，该蛋白也被抗血清型M1抗血清识别，但仅与人IgG3 （IIb型）表现出显著的非免疫反应性。对分离物的提取物进行了与人IgA、纤维蛋白原和白蛋白的反应性分析。人血浆蛋白与致病性A组链球菌结合的重要性仍有待确定。
Invasive group A streptococcal isolates collected as part of a Centers for Disease Control and Prevention surveillance study were analyzed for expression of immunoglobulin G (IgG)-binding proteins. Two IgG-binding phenotypes of group A isolates of the M1 serotype were identified. The first group expressed a surface protein that bound all four human IgG subclasses (type IIo) and was recognized by rabbit anti-serotype M1-specific antiserum but not by normal rabbit serum. The second group expressed an IgG-binding protein that was also recognized by the anti-serotype M1 antiserum but demonstrated significant nonimmune reactivity only with human IgG3 (type IIb). Analysis of extracts of the isolates for reactivity with human IgA, fibrinogen, and albumin was also performed. The importance of the binding of human plasma proteins to pathogenic group A streptococci remains to be established.