The discharge behaviour of single sympathetic neurones supplying human sweat glands
The discharge behaviour of single sympathetic neurones supplying human sweat glands
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DOI：
10.1016/s0165-1838(96)00095-1
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发表时间：
1996-12-14
期刊：
影响因子：
--
通讯作者：
Wallin, BG
中科院分区：
文献类型：
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作者：
Macefield, VG;Wallin, BG
通过将钨微电极插入清醒受试者腓神经皮束，研究了单个催汗轴突的放电特性。出汗是由辐射热引起的，并通过足背神经支配区域内皮肤电阻的变化来测量。8个单位被归类为催汗神经元，因为尖峰触发平均揭示了单位放电和随后的皮肤电阻下降（1.12 +/- 0.05 s）之间的时间锁定关系，但与皮肤血流无关（通过激光多普勒探头测量）。催汗单位通常在交感神经爆发中只发射一个（最多六个）尖峰。平均放电频率为0.62 Hz，但可产生50 Hz以上的瞬时频率。R波触发直方图和相干性分析显示，三个催汗神经元的发射和心电图之间的显着耦合。此外，四个催汗神经元的发射表现出微弱但显着的相关性与心脏间期，舒张压，或动脉压下降率的自发波动。我们的结论是，人类催汗神经元的放电调制压力感受器输入。
Firing properties of single sudomotor axons were studied via tungsten microelectrodes inserted percutaneously into cutaneous fascicles of the peroneal nerve in awake subjects. Sweating was induced by radiant heat and measured by changes in skin electrical resistance within the innervation territory on the dorsum of the foot. Eight units were classified as sudomotor neurones because spike-triggered averaging revealed a time-locked relationship between the unitary discharge and the subsequent decrease in skin resistance (1.12 +/- 0.05 s), but no relationship to skin blood flow (measured by a laser-doppler probe). Sudomotor units usually fired only one (maximum six) spike(s) in a sympathetic burst. The mean firing rate was 0.62 Hz, but instantaneous frequencies above 50 Hz could be generated. R-wave triggered histograms and coherence analysis revealed significant coupling between the firing of three sudomotor neurones and the ECG. Moreover, the firing of four sudomotor neurones showed a weak but significant correlation with the spontaneous fluctuations in cardiac interval, diastolic pressure, or the rate of fall in arterial pressure. We conclude that the discharge of human sudomotor neurones is modulated by baroreceptor input.