Quantitative measurement of carotid intima-media roughness -: effect of age and manifest coronary artery disease
Quantitative measurement of carotid intima-media roughness -: effect of age and manifest coronary artery disease
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DOI：
10.1016/s0021-9150(02)00245-9
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发表时间：
2003-01-01
期刊：
影响因子：
5.3
通讯作者：
Huonker, M
中科院分区：
文献类型：
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作者：
Schmidt-Trucksäss, A;Sandrock, M;Huonker, M
颈总动脉 (CCA) 的动脉粥样硬化变化在 B 型超声中可能表现为内膜中层厚度（缩写为 IM 粗糙度）不规则。本研究的目的是调查 CCA IM 粗糙度是否随年龄变化以及假定健康个体和冠状动脉疾病 (CAD) 患者之间是否存在差异。方法和结果：基于新的自动识别 (AI) 程序，在 15 名年轻志愿者和 22 名健康老年志愿者以及 46 名已知 CAD 患者的 B 型图像中测量了 CCA 远壁的节段内膜中层厚度 (IMT) 和 IM 粗糙度。平均和最大CCA IMT在年轻组中最低（0.55+/-0.05; 0.65+/-0.06 mm），在老年组中较高（0.77+/-0.16; 0.87+/-0.18 mm），在CAD患者中最高（0.88+/-0.18; 1.01+/-0.27 mm）（所有组中P < 0.01）。迄今为止，CAD 患者的 CCA IM 粗糙度最大（0.075+/-0.02 mm；与两组相比，P < 0.0 1），并且随着年龄的增长仅略有增加（年轻：0.035+/-0.008 mm；老年：0.040+/-0.014 mm；P < 0.05）。预测 CAD 患者的受试者工作特征曲线 (ROC) 的曲线下面积 (AUC)，CCA IM 粗糙度 (0.80) 高于平均 IMT (0.66) 和最大 IMT (0.71)。结论：CCA IM 粗糙度随着年龄的增长而增加，并且比 CCA 平均和最大 IMT 更有助于区分假定健康的个体和患有明显 CAD 的患者。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Atherosclerotic changes of the common carotid artery (CCA) may appear like irregularities of the intima-media thickness (abbreviated as IM roughness) in B-mode ultrasound. The purposes of the present study were to investigate whether the CCA IM roughness changes with age and differs between individuals presumed to be healthy and patients with coronary artery-disease (CAD). Methods and results: Based on a new automatic identification (AI) program, the segmental intima-media thickness (IMT) and IM roughness of the CCA far wall were measured in B-mode images of 15 younger and 22 older volunteers presumed to be healthy, and 46 patients with known CAD. The mean and maximum CCA IMT were lowest in the young group (0.55+/-0.05; 0.65+/-0.06 mm), higher in the older group (0.77+/-0.16; 0.87+/-0.18 mm) and highest in CAD patients (0.88+/-0.18; 1.01+/-0.27 mm) (P < 0.01 among all groups). The CCA IM roughness was greatest by far in the CAD patients (0.075+/-0.02 mm; P < 0.0 1 vs. both groups) and increased only slightly with age (younger: 0.035+/-0.008 mm; older: 0.040+/-0.014 mm; P < 0.05). Areas under the curve (AUC) of receiver-operating characteristic curves (ROC) predicting patients with CAD were higher for the CCA IM roughness (0.80) than for the mean (0.66) and maximum IMT (0.71). Conclusions: It is suggested that the CCA IM roughness increases with age, and helps to discriminate between individuals presumed to be healthy and patients with manifest CAD better than the CCA mean and maximum IMT. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.