Investigating placebo effects in irritable bowel syndrome: A novel research design
Investigating placebo effects in irritable bowel syndrome: A novel research design
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DOI：
10.1016/j.cct.2005.11.012
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发表时间：
2006-04-01
影响因子：
2.2
通讯作者：
Kerr, CE
中科院分区：
文献类型：
--
作者：
Conboy, LA;Wasserman, RH;Kerr, CE
人们对安慰剂效应的科学精确性知之甚少。糟糕的方法混淆了我们对安慰剂效应的大小甚至存在的理解。研究安慰剂效应提出了特殊的研究挑战，包括：研究安慰剂效应的适当控制的设计，包括从自然史和回归到平均值，需要大样本量来捕捉预期的小效应，以及需要从患者的角度来理解这种潜在的影响。本文总结了一项正在进行的NIH资助的随机对照试验的方法，该试验旨在调查肠易激综合征（IBS）中是否存在安慰剂效应，以及这种效应的大小是否可以以类似于“剂量依赖性”的方式进行操纵。该试验还采用了定量和定性方法的创新组合。(c)2005年爱思唯尔公司All rights reserved.
Little is known about placebo effects with scientific precision. Poor methodology has confounded our understanding of the magnitude and even the existence of the placebo effect. Investigating placebo effects presents special research challenges including: the design of appropriate controls for studying placebo effects including separating such effects from natural history and regression to the mean, the need for large sample sizes to capture expected small effects, and the need to understand such potential effects from a patient's perspective. This article summarizes the methodology of an ongoing NIH-funded randomized controlled trial aimed at investigating whether the placebo effect in irritable bowel syndrome (IBS) exists and whether the magnitude of such an effect can be manipulated to vary in a manner analogous to '' dose dependence.'' The trial also uses an innovative combination of quantitative and qualitative methods. (c) 2005 Elsevier Inc. All rights reserved.