MICROCALCIFICATIONS IN BENIGN BREAST DISEASES - A HISTOLOGICAL AND HISTOCHEMICAL-STUDY
MICROCALCIFICATIONS IN BENIGN BREAST DISEASES - A HISTOLOGICAL AND HISTOCHEMICAL-STUDY
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DOI：
10.1016/s0344-0338(84)80105-3
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发表时间：
1984-01-01
影响因子：
2.8
通讯作者：
GOGAS, I
中科院分区：
文献类型：
--
作者：
ANASTASSIADES, OT;BOUROPOULOU, V;GOGAS, I
纤维腺瘤（100例）和良性乳腺疾病（300例）进行了研究，以前没有X线检查的标本。19%的纤维腺瘤、26%的纤维性疾病和57%的纤维囊性疾病中发现微钙化。正常乳腺组织未见良性微钙化。它们与化生上皮细胞及其异常分泌物密切相关。遇到两种基本类型的微钙化：颗粒状微钙化，主要是细胞内的位置和均匀的（有或没有同心环），主要与分泌物质。微钙化与小的嗜酸性化生上皮细胞及其分泌物、泡沫细胞和顶浆分泌细胞分泌的物质有关。在含有微钙化的细胞或基质中，一个共同的组织化学特征是复合脂质的存在。良性乳腺微钙化与其他组织钙化的可能关系，与他们的协会与脂质进行了讨论。
Cases of fibroadenomas (100) and benign breast diseases (300) were studied without previous roentgenographic examination of the specimens. Microcalcifications were found in 19% of the fibroadenomas, in 26% of the cases of fibrous disease and in 57% of the cases of fibrocystic disease. Benign microcalcifications were not found in normal mammary tissue. They were steadily associated with metaplastic epithelial cells and with their abnormal secretions. Two basic types of microcalcifications were encountered: the granular microcalcifications with a predominately intracellular location and the homogeneous (with or without concentric rings) mainly associated with secreted materials. Microcalcifications were associated with metaplastic epithelial cells of the small eosinophilic variety and with their secretions, with the foam cells and with materials secreted by the apocrine cells. A common histochemical feature in cells or matrixes containing microcalcifications was the presence of compound lipids. The possible relationship of benign breast microcalcifications to the calcifications of other tissues, in connection with their association with lipids is discussed.