Whole-proteome differential screening identifies novel vaccine candidates for schistosomiasis japonica.
Whole-proteome differential screening identifies novel vaccine candidates for schistosomiasis japonica.
复制标题
DOI：
10.1093/infdis/jiab085
复制
发表时间：
2021-02
期刊：
影响因子：
--
通讯作者：
Hannah W Wu;Sangshin Park;Sunthorn Pond-Tor;Ron Stuart;Sha Zhou;Yang Hong;A. Ruiz;L. Acosta
中科院分区：
文献类型：
--
作者：
Hannah W Wu;Sangshin Park;Sunthorn Pond-Tor;Ron Stuart;Sha Zhou;Yang Hong;A. Ruiz;L. Acosta
Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel. Using our whole proteome differential screening approach, and plasma and epidemiologic data from a longitudinal cohort of individuals living in a Schistosoma japonicum endemic region of the Philippines, we interrogated the parasite proteome to identify novel vaccine candidates for Schistosoma japonicum. We identified sixteen parasite genes which encoded proteins that were recognized by IgG or IgE antibodies in the plasma of individuals who had developed resistance to reinfection, but were not recognized by antibodies in the plasma of individuals who remained susceptible to reinfection. Antibody levels to Sj6-8 and Sj4-1 measured in the entire cohort (n=505) one month after praziquantel treatment were associated with significantly decreased risk of reinfection and lower intensity of reinfection over 18 months of follow-up.
