FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
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DOI：
10.1006/cyto.1999.0485
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发表时间：
1999-10-01
期刊：
影响因子：
3.8
通讯作者：
Gurney, AL
中科院分区：
文献类型：
--
作者：
Xie, MH;Holcomb, I;Gurney, AL
我们已经确定了一种新的成纤维细胞生长因子，FGF-19，迄今为止描述的FGF家族的最远的成员。FGF-19是FGFR 4的高亲和力肝素依赖性配体，并且是FGF家族中第一个显示出与FGFR 4排他性结合的成员。人FGF-19定位于染色体11 q13.1，这是一个与骨骼和视网膜缺陷的神经胶质瘤-假神经胶质瘤综合征相关的区域。FGF-19信使在几种组织中表达，包括胎儿软骨、皮肤和视网膜，以及成人胆囊，并且在结肠腺癌细胞系中过表达。(C)北京：科学出版社.
We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. (C) 1999 Academic Press.