Histone H4 histidine phosphorylation: kinases, phosphatases, liver regeneration and cancer
Histone H4 histidine phosphorylation: kinases, phosphatases, liver regeneration and cancer
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DOI：
10.1042/bst20110605
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Attwood, Paul V.
中科院分区：
文献类型：
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作者：
Besant, Paul G.;Attwood, Paul V.
组蛋白H4在其两个组氨酸残基中的一个或两个上的磷酸化已经已知在肝细胞中发生了近40年，并且已经与机械损伤后肝脏再生期间的肝细胞增殖相关。最近，已经发现组蛋白H4组氨酸激酶活性的大幅增加与防止肝细胞增殖的化学损伤后肝祖细胞的增殖和分化相关。此外，已经显示，与正常成人肝脏相比，这种组蛋白H4组氨酸激酶活性在人胎儿肝脏中升高近100倍，在肝细胞癌组织中升高数百倍。本文综述了组蛋白H4组氨酸磷酸化的研究进展、相关的激酶以及催化组蛋白H4去磷酸化的磷酸酶，并简要总结了检测组蛋白H4组氨酸磷酸化及其激酶活性的技术。
Phosphorylation of histone H4 on one or both of its two histidine residues has been known to occur in liver cells for nearly 40 years and has been associated with proliferation of hepatocytes during regeneration of the liver following mechanical damage. More recently, large increases in histone H4 histidine kinase activity have been found to occur associated with proliferation and differentiation of liver progenitor cells following chemical damage that prevents hepatocyte proliferation. In addition, it has been shown this histone H4 histidine kinase activity is elevated nearly 100-fold in human foetal liver and several hundredfold in hepatocellular carcinoma tissue compared with normal adult liver. In the present paper, we review what is currently known about histone H4 histidine phosphorylation, the kinase(s) responsible and the phosphatases capable of catalysing its dephosphorylation, and briefly summarize the techniques used to detect and measure the histidine phosphorylation of histone H4 and the corresponding kinase activity.