Exploitation of mammalian host cell functions by bacterial pathogens
Exploitation of mammalian host cell functions by bacterial pathogens
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DOI：
10.1126/science.276.5313.718
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发表时间：
1997-05-02
期刊：
影响因子：
56.9
通讯作者：
Cossart, P
中科院分区：
文献类型：
--
作者：
Finlay, BB;Cossart, P
由于抗生素耐药性、新病原体的出现和旧病原体的死灰复燃以及缺乏有效的治疗方法，对细菌发病机制的兴趣最近有所增加。微生物发病机制的分子和细胞机制目前正在被定义，对多种致病菌使用的共同策略和单个物种进化的独特策略都有精确的了解，以帮助建立感染。正在出现的是对细菌病原体如何与宿主细胞相互作用的新认识。许多宿主细胞的功能，包括信号转导途径，细胞骨架重排和液泡运输，被利用，这些是这篇综述的重点。这项工作的一个好处是，细菌毒力因子为研究哺乳动物细胞功能的各个方面提供了新的工具，除了细菌疾病的机制之外，这些发展可能会导致新的治疗策略。
Interest in bacterial pathogenesis has recently increased because of antibiotic resistance, the emergence of new pathogens and the resurgence of old ones, and the lack of effective therapeutics. The molecular and cellular mechanisms of microbial pathogenesis are currently being defined, with precise knowledge of both the common strategies used by multiple pathogenic bacteria and the unique tactics evolved by individual species to help establish infection. What is emerging is a new appreciation of how bacterial pathogens interact with host cells. Many host cell functions, including signal transduction pathways, cytoskeletal rearrangements, and vacuolar trafficking, are exploited, and these are the focus of this review. A bonus of this work is that bacterial virulence factors are providing new tools to study various aspects of mammalian cell functions, in addition to mechanisms of bacterial disease, Together these developments may lead to new therapeutic strategies.