Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.
Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis.
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2019冠状病毒病住院患者静脉血栓栓塞和出血的发生率：系统综述和荟萃分析
DOI：
10.1016/j.chest.2020.11.005
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发表时间：
2021-03
期刊：
影响因子：
9.6
通讯作者：
Monreal M
中科院分区：
文献类型：
--
作者：
Jiménez D;García-Sanchez A;Rali P;Muriel A;Bikdeli B;Ruiz-Artacho P;Le Mao R;Rodríguez C;Hunt BJ;Monreal M
个别研究报告称，2019 年冠状病毒病 (COVID-19) 住院患者的 VTE 和出血发生率差异很大。 COVID-19 住院患者的 VTE 和出血发生率是多少？在本次系统回顾和荟萃分析中，检索了2020年1月1日至2020年7月31日期间的15个标准来源和特定于COVID-19的来源，不受语言限制。通过使用随机效应荟萃分析来汇总发病率估计值。使用 I2 统计量评估异质性，并使用 Begg 和 Egger 检验评估发表偏倚。 VTE 的汇总发生率为 17.0%（95% CI，13.4-20.9），DVT 为 12.1%（95% CI，8.4-16.4），肺栓塞（PE）为 7.1%（95% CI，5.3-9.1），肺栓塞（PE）为 7.8%（95% CI，2.6-15.3）。出血，大出血为 3.9%（95% CI，1.2-7.9）。在亚组荟萃分析中，根据筛查（临床诊断为 33.1% 对比 9.8%）、ICU 患者（病房中 27.9% 对比 7.1%）、前瞻性研究（回顾性研究中 25.5% 对比 12.4%）以及纳入导管相关血栓/孤立性远端 DVT 和孤立性亚段性静脉血栓形成的情况进行评估，VTE 的发生率较高。 PE。据报告，接受中剂量或全剂量抗凝治疗的患者出血发生率汇总最高（21.4%），而在唯一评估出血事件的前瞻性研究中出血发生率最低（2.7%）。在住院的 COVID-19 患者中，VTE 的总体估计汇总发生率为 17.0%，在危重患者和前瞻性研究中，常规筛查、纳入远端 DVT 和亚段 PE 的发生率较高。 7.8% 的患者观察到出血事件，并且对增加剂量的抗凝剂的使用和数据收集的性质很敏感。需要进行更多研究来确定各种血栓事件的重要性并确定改善患者预后的策略。普洛斯彼罗；编号：CRD42020198864；网址：https://www.crd.york.ac.uk/prospero/。
Individual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19). What is the incidence of VTE and bleeding among hospitalized patients with COVID-19? In this systematic review and meta-analysis, 15 standard sources and COVID-19-specific sources were searched between January 1, 2020, and July 31, 2020, with no restriction according to language. Incidence estimates were pooled by using random effects meta-analyses. Heterogeneity was evaluated by using the I2 statistic, and publication bias was assessed by using the Begg and Egger tests. The pooled incidence was 17.0% (95% CI, 13.4-20.9) for VTE, 12.1% (95% CI, 8.4-16.4) for DVT, 7.1% (95% CI, 5.3-9.1) for pulmonary embolism (PE), 7.8% (95% CI, 2.6-15.3) for bleeding, and 3.9% (95% CI, 1.2-7.9) for major bleeding. In subgroup meta-analyses, the incidence of VTE was higher when assessed according to screening (33.1% vs 9.8% by clinical diagnosis), among patients in the ICU (27.9% vs 7.1% in the ward), in prospective studies (25.5% vs 12.4% in retrospective studies), and with the inclusion of catheter-associated thrombosis/isolated distal DVTs and isolated subsegmental PEs. The highest pooled incidence estimate of bleeding was reported for patients receiving intermediate- or full-dose anticoagulation (21.4%) and the lowest in the only prospective study that assessed bleeding events (2.7%). Among hospitalized patients with COVID-19, the overall estimated pooled incidence of VTE was 17.0%, with higher rates with routine screening, inclusion of distal DVT, and subsegmental PE, in critically ill patients and in prospective studies. Bleeding events were observed in 7.8% of patients and were sensitive to use of escalated doses of anticoagulants and nature of data collection. Additional studies are required to ascertain the significance of various thrombotic events and to identify strategies to improve patient outcomes. PROSPERO; No.: CRD42020198864; URL: https://www.crd.york.ac.uk/prospero/.
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影响因子：
7.5
作者：
Bikdeli B;Talasaz AH;Rashidi F;Sharif-Kashani B;Farrokhpour M;Bakhshandeh H;Sezavar H;Dabbagh A;Beigmohammadi MT;Payandemehr P;Yadollahzadeh M;Riahi T;Khalili H;Jamalkhani S;Rezaeifar P;Abedini A;Lookzadeh S;Shahmirzaei S;Tahamtan O;Matin S;Amin A;Parhizgar SE;Jimenez D;Gupta A;Madhavan MV;Parikh SA;Monreal M;Hadavand N;Hajighasemi A;Maleki M;Sadeghian S;Mohebbi B;Piazza G;Kirtane AJ;Lip GYH;Krumholz HM;Goldhaber SZ;Sadeghipour P
通讯作者：
Sadeghipour P
DOI：
10.1111/jth.14849
发表时间：
2020-07
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Fernandez-Capitan, Carmen;Barba, Raquel;Monreal, Manuel
通讯作者：
Monreal, Manuel
COVID-19危重患者的 DVT 发生率和危险因素
影响因子：
4
作者：
Chen, Shujing;Zhang, Dingyu;Jiang, Jinjun
通讯作者：
Jiang, Jinjun
影响因子：
10.4
作者：
Cui, Songping;Chen, Shuo;Wang, Feng
通讯作者：
Wang, Feng