Steroidogenic organ development and homeostasis: A WT1-centric view
Steroidogenic organ development and homeostasis: A WT1-centric view
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DOI：
10.1016/j.mce.2015.01.009
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发表时间：
2015-06-15
影响因子：
4.1
通讯作者：
Schedl, Andreas
中科院分区：
文献类型：
--
作者：
Bandiera, Roberto;Sacco, Sonia;Schedl, Andreas
肾上腺和性腺是脊椎动物体内主要的类固醇生成器官，是调节体内稳态的中心。虽然肾上腺和性腺在成年生物体中是分开的，但这两个器官有一个共同的发育起源，即肾上腺性腺原基。参与这两个器官发育的关键基因之一是Wilms肿瘤抑制因子WT1，它编码一种锌指蛋白，二十多年来一直吸引着科学界。本次审查将提供一个概述的过程中，导致这些独特的器官的发展，特别关注的多功能WT 1在肾上腺性腺发育过程中服务。此外，我们将强调一些最近的发现和开放的问题，如何维持类固醇器官是在成年生物体。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Adrenal and gonads are the main steroidogenic organs and are central to regulate body homeostasis in the vertebrate organism. Although adrenals and gonads are physically separated in the adult organism, both organs share a common developmental origin, the adrenogonadal primordium. One of the key genes involved in the development of both organs is the Wilms' tumor suppressor WT1, which encodes a zinc finger protein that has fascinated the scientific community for more than two decades. This review will provide an overview of the processes leading to the development of these unique organs with a particular focus on the multiple functions WT1 serves during adrenogonadal development. In addition, we will highlight some recent findings and open questions on how maintenance of steroidogenic organs is achieved in the adult organism. (C) 2015 Elsevier Ireland Ltd. All rights reserved.