Inflammatory Markers Related to Microbial Translocation Among HIV-Infected Pregnant Women: A Risk Factor of Preterm Delivery
Inflammatory Markers Related to Microbial Translocation Among HIV-Infected Pregnant Women: A Risk Factor of Preterm Delivery
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DOI：
10.1093/infdis/jiv416
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发表时间：
2016-02-01
影响因子：
6.4
通讯作者：
Palacio, Montse
中科院分区：
文献类型：
--
作者：
Lopez, Marta;Figueras, Francesc;Palacio, Montse
背景。本研究旨在评估脂多糖调节剂作为人类免疫缺陷病毒（HIV）感染妇女妊娠期微生物易位标记物的作用，并评估其与早产的关系。方法：本研究采用前瞻性队列设计，在西班牙巴塞罗那医院诊所进行。包括36名感染艾滋病毒的孕妇和36名未感染艾滋病毒的孕妇，根据年龄和胎次进行匹配。在妊娠早期、妊娠晚期和分娩时采集母体血液样本。测定可溶性CD14 （sCD14）、人脂多糖结合蛋白（LBP）、免疫球蛋白M内毒素脂多糖核心抗体（EndoCAb）和白细胞介素6 （IL-6）水平。测定胎儿脐带血sCD14、LBP和IL-6水平。结果：hiv感染组妊娠早期sCD14和LBP水平及妊娠晚期sCD14水平显著升高。与足月分娩的感染艾滋病毒的妇女或艾滋病毒阴性妇女相比，感染艾滋病毒的早产和自发性早产妇女在整个妊娠期间sCD14水平显著升高，在妊娠头三个月期间LBP水平显著升高。在多变量分析中，观察到hiv感染妇女妊娠早期sCD14水平与早产之间的独立关联。结论：这是第一个评估hiv感染妇女妊娠期间与微生物易位相关的炎症标志物的研究。在感染艾滋病毒的孕妇中观察到较高水平的sCD14和LBP，并与早产有关。
Background. This study was performed to assess the role of lipopolysaccharide modulators as a marker of microbial translocation among human immunodeficiency virus (HIV)-infected women during pregnancy and to evaluate their association with preterm delivery.Methods.The study had a prospective cohort design and was performed at the Hospital Clinic in Barcelona, Spain. Thirty-six pregnant women with and 36 without HIV infection, matched on the basis of age and parity, were included. Maternal blood samples were obtained during the first trimester, during the third trimester, and at delivery. Levels of soluble CD14 (sCD14), human lipopolysaccharide-binding protein (LBP), immunoglobulin M endotoxin core antibodies to lipopolysaccharide (EndoCAb), and interleukin 6 (IL-6) were determined. Fetal cord blood levels of sCD14, LBP, and IL-6 were determined. Results were compared between groups.Results.First trimester sCD14 and LBP levels and third trimester sCD14 levels were significantly higher in the HIV-infected group. HIV-infected women with preterm births and spontaneous preterm births had significantly increased levels of sCD14 throughout pregnancy and significantly increased levels of LBP during the first trimester, compared with HIV-infected women with delivery at term or with HIV-negative women. On multivariate analysis, an independent association was observed between first trimester sCD14 levels and preterm delivery among HIV-infected women.Conclusions.This is the first study to assess inflammatory markers related to microbial translocation during pregnancy among HIV-infected women. Higher levels of sCD14 and LBP were observed in HIV-infected pregnant women and were associated with preterm delivery.