Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces.
Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces.
复制标题
DOI：
10.1186/1471-2202-10-145
复制
发表时间：
2009-12-10
期刊：
影响因子：
2.4
通讯作者：
Zald DH
中科院分区：
文献类型：
--
作者：
Blackford JU;Avery SN;Shelton RC;Zald DH
受抑制的气质--对具有戒心或回避行为的新人、新地点或新事物做出反应的倾向--与社交焦虑症和严重抑郁的风险增加有关。虽然杏仁核对新奇事物的反应大小已被确认为抑制气质的神经底物，但在时间动力学(潜伏期、持续时间和峰值)上也可能存在差异。我们假设，与不受约束气质的人相比，与熟悉的中性面孔相比，受抑制气质的人对小说的反应更快。我们使用事件相关功能磁共振成像来测量抑制或不抑制气质的参与者对新的和熟悉的中性面孔的血氧水平依赖(BOLD)反应的时间动力学。与熟悉的面孔相比，受抑制的参与者对新奇面孔的杏仁核反应更快，对所有面孔的杏仁核反应都更长、更大。两组的峰值反应无差异。杏仁核对新奇事物更快的反应可能反映了一种计算偏见，这种偏见导致了更大的新恐惧症反应，并代表了一种发展社交焦虑的机制。
Inhibited temperament - the predisposition to respond to new people, places or things with wariness or avoidance behaviors - is associated with increased risk for social anxiety disorder and major depression. Although the magnitude of the amygdala's response to novelty has been identified as a neural substrate of inhibited temperament, there may also be differences in temporal dynamics (latency, duration, and peak). We hypothesized that persons with inhibited temperament would have faster responses to novel relative to familiar neutral faces compared to persons with uninhibited temperament. We used event-related functional magnetic resonance imaging to measure the temporal dynamics of the blood oxygen level dependent (BOLD) response to both novel and familiar neutral faces in participants with inhibited or uninhibited temperament. Inhibited participants had faster amygdala responses to novel compared with familiar faces, and both longer and greater amygdala response to all faces. There were no differences in peak response. Faster amygdala response to novelty may reflect a computational bias that leads to greater neophobic responses and represents a mechanism for the development of social anxiety.