Catheter-directed thrombolysis for lower extremity deep venous thrombosis: Report of a national multicenter registry
Catheter-directed thrombolysis for lower extremity deep venous thrombosis: Report of a national multicenter registry
复制标题
DOI：
10.1148/radiology.211.1.r99ap4739
复制
发表时间：
1999-04-01
期刊：
影响因子：
19.7
通讯作者：
Haughton, SH
中科院分区：
文献类型：
--
作者：
Mewissen, MW;Seabrook, GR;Haughton, SH
目的：评估导管定向溶栓治疗症状性下肢深静脉血栓 (DVT) 的效果。 材料和方法：根据症状性下肢 DVT 患者 (n = 473) 的登记，对 287 名患者（137 名男性和 150 名女性患者；平均年龄 47.5 岁）的 303 个肢体进行 312 次尿激酶输注结果分析了。 188 名患者 (66%) 的 DVT 症状为急性（小于或等于 10 天），45 名患者（16%）为慢性（>10 天），54 名患者（19%）为急性和慢性。 90 人（31%）有 DVT 病史。使用静脉造影结果计算溶解等级。 结果：髂股 DVT (n = 221 [71%]) 和股腘 DVT (n = 79 [25%]) 接受尿激酶输注（平均 780 万国际单位）治疗平均 53.4 小时。溶栓后，对99处髂静脉和5处股静脉病变进行了支架治疗。 96 次（31%）输注实现了 III 级（完全）裂解； II 级（50%-99% 裂解），162 例（52%）；和一级（
PURPOSE: To evaluate catheter-directed thrombolysis for treatment of symptomatic lower extremity deep venous thrombosis (DVT).MATERIALS AND METHODS: From a registry of patients (n = 473) with symptomatic lower limb DVT, results of 312 urokinase infusions in 303 limbs of 287 patients (137 male and 150 female patients; mean age, 47.5 years) were analyzed. DVT symptoms were acute (less than or equal to 10 days) in 188 (66%) patients, chronic (>10 days) in 45 (16%), and acute and chronic in 54 (19%). A history of DVT existed in 90 (31%). Lysis grades were calculated by using venographic results.RESULTS: Iliofemoral DVT (n = 221 [71%]) and femoral-popliteal DVT (n = 79 [25%]) were treated with urokinase infusions (mean, 7.8 million IU) for a mean of 53.4 hours. After thrombolysis, 99 iliac and five femoral vein lesions were treated with stents. Grade III (complete) lysis was achieved in 96 (31%) infusions; grade II (50%-99% lysis), in 162 (52%); and grade I (