Lupus Vasculitis
Lupus Vasculitis
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DOI：
10.1007/s11926-020-00937-0
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发表时间：
2020-08-26
影响因子：
5
通讯作者：
Abril, Andy
中科院分区：
文献类型：
--
作者：
Calle-Botero, Estefania;Abril, Andy
综述的目的本文旨在回顾与系统性红斑狼疮（SLE）患者血管炎相关的最新文献，包括先前发表的标志性文章和研究，并更新这种重要自身免疫性疾病患者血管炎表现的不同临床和诊断方面。作为一种多系统自身免疫性疾病，系统性狼疮几乎可以攻击人体内的任何器官系统。尽管血管炎不是最常见的疾病表现或致病机制，但它经常导致SLE患者的显著发病率和死亡率。狼疮性血管炎最常见的表现是皮肤受累;内脏受累较少见，但可引起严重疾病;它可以发生在不同的领域，包括中枢神经系统，周围神经系统，胃肠道系统，肾脏，肺，甚至视网膜。最近的发现最近的发现有关狼疮中枢神经系统和周围神经疾病的发病机制，血管炎是系统性红斑狼疮的一种少见但严重的临床表现;它可能涉及不同的器官系统，并出现在各种各样的临床综合征中，因此，处理这种疾病的医生识别和早期诊断的重要性，以便在指示时开始迅速和积极的治疗。
Purpose of Review The purpose of this manuscript is to review the most recent literature pertinent to the presence of vasculitis in patients with systemic lupus erythematosus (SLE), including previously published landmark articles and studies and to update the different clinical and diagnostic aspects of vasculitic manifestations in patients with this important autoimmune disorder. As a multisystem autoimmune disease, systemic lupus may attack practically any organ system in the human body. Even though vasculitis is not the most common presentation or pathogenic mechanism of disease, it frequently causes significant morbidity and mortality in patients with SLE. The most common manifestation of lupus vasculitis is cutaneous involvement; visceral involvement is less common but causes severe disease; it may occur in different areas including central nervous system, peripheral nervous system, gastrointestinal system, kidneys, lungs and even retina.Recent Findings Recent findings regarding the pathogenesis of lupus CNS and peripheral nerve disease, and vascular injury in lupus nephritis are reviewed as well.Summary Vasculitis is an uncommon but serious manifestation of SLE; it may involve different organ systems and present in a wide variety of clinical syndromes, and thus the importance of its recognition and early diagnosis by physicians who deal with this disease, in order to start prompt and aggressive therapy when indicated.