The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19).
The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19).
复制标题
DOI：
10.3390/ijms21176412
复制
发表时间：
2020-09-03
影响因子：
5.6
通讯作者：
Yu AM
中科院分区：
文献类型：
--
作者：
Batra N;De Souza C;Batra J;Raetz AG;Yu AM
2019冠状病毒病（COVID-19）或严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）感染是一种全球性大流行病，发病率和死亡率不断上升。基于严重COVID-19病例细胞因子谱的最新证据表明，在感染SARS-CoV-2的患者中，巨噬细胞和单核细胞的过度刺激与T细胞丰度降低（淋巴细胞减少症）相关。通过高通量筛选实验发现SARS-CoV-2开放阅读框3a（ORF 3a）蛋白以高置信度与人HMOX 1蛋白结合。HMOX 1通路可以抑制血小板聚集，并且可以具有抗血栓形成和抗炎特性等，所有这些都是在COVID-19患者中观察到的关键医学病症。在这里，我们回顾了调节HMOX 1-ORF 3a关系以调节先天免疫应答以获得COVID-19患者治疗益处的潜力。我们还审查了其他潜在的治疗策略，并提出了新的合成和天然化合物，可能有潜力在临床上的未来发展。
The coronavirus disease of 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global pandemic with increasing incidence and mortality rates. Recent evidence based on the cytokine profiles of severe COVID-19 cases suggests an overstimulation of macrophages and monocytes associated with reduced T-cell abundance (lymphopenia) in patients infected with SARS-CoV-2. The SARS-CoV-2 open reading frame 3 a (ORF3a) protein was found to bind to the human HMOX1 protein at a high confidence through high-throughput screening experiments. The HMOX1 pathway can inhibit platelet aggregation, and can have anti-thrombotic and anti-inflammatory properties, amongst others, all of which are critical medical conditions observed in COVID-19 patients. Here, we review the potential of modulating the HMOX1-ORF3a nexus to regulate the innate immune response for therapeutic benefits in COVID-19 patients. We also review other potential treatment strategies and suggest novel synthetic and natural compounds that may have the potential for future development in clinic.
登录
查看更多内容
影响因子：
37.3
作者：
Donati B;Lorenzini E;Ciarrocchi A
通讯作者：
Ciarrocchi A
影响因子：
15.9
作者：
Chung, Su Wol;Liu, Xiaoli;Perrella, Mark A.
通讯作者：
Perrella, Mark A.
影响因子：
5.3
作者：
Cobos EJ;Entrena JM;Nieto FR;Cendán CM;Del Pozo E
通讯作者：
Del Pozo E
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
12.7
作者：
Antony, Suresh J.;Davis, Michelle A.;Prakash, Bharat, V
通讯作者：
Prakash, Bharat, V