Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cells
Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cells
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DOI：
10.1002/adma.200701975
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发表时间：
2007-10-19
影响因子：
29.4
通讯作者：
Sun, Shouheng
中科院分区：
文献类型：
--
作者：
Xie, Jin;Xu, Chenjie;Sun, Shouheng
合成了一种基于多巴胺-聚乙二醇的配体，并用于在生理条件下稳定单分散的9纳米Fe3O4纳米颗粒，并防止巨噬细胞的非特异性摄取。这种稳定的纳米颗粒可用于提高靶向药物递送的效率，并提高磁共振成像（MRI）的信噪比。
A dopamine-PEG based ligand is synthesized and used to stabilize monodisperse 9 nm Fe3O4 nanoparticles in physiological conditions and against non-specific uptake by macrophage cells. Such stable nanoparticles can be used to enhance the efficiency in target-specific drug delivery and to increase the signal-to-noise ratio in magnetic resonance imaging (MRI).