A study on a special DNA nanotube assembled from two single-stranded tiles
A study on a special DNA nanotube assembled from two single-stranded tiles
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由两条单链瓦片组装而成的特殊 DNA 纳米管的研究
DOI：
10.1088/1361-6528/aaf9bc
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发表时间：
2019-03-15
期刊：
影响因子：
3.5
通讯作者：
Pan，Linqiang
中科院分区：
文献类型：
--
作者：
Xu，Fei;Wu，Tingfang;Pan，Linqiang
单链瓦（SST）策略提供了对纳米管周长的精确控制，而自组装过程中的动力学陷阱阻止了更宽管的形成。在这里，我们报告了一种简单有效的方法，通过一锅退火，仅使用2个SSTs构建DNA纳米管。2-SST纳米管的直径比动力学陷阱理论预测的要大得多，这表明在这些纳米管的形成过程中有一种新的机制在起作用。进一步的研究表明，2-SST纳米管是通过分层途径组装的，其中包括2-SST纳米线的中间形成。
Single-stranded tile (SST) strategy offers precise control over the circumferences of nanotubes while the kinetic trap in the process of the self-assembly prevents the formation of wider tubes. Here, we report a simple and efficient method to build DNA nanotubes using only 2 SSTs via one-pot annealing. The diameters of the 2-SST nanotubes were much larger than what the kinetic trap theory would predict, indicating a new mechanism was at play in the formation of these nanotubes. Further investigation suggested that the 2-SST nanotubes were assembled through a hierarchical pathway that involved an intermediate formation of 2-SST nano-lines.