The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.
The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.
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英国生物库中的体力活动与青光眼及相关特征协会。
DOI：
10.1016/j.ophtha.2023.06.009
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发表时间：
2023
期刊：
影响因子：
13.7
通讯作者：
ModifiableRiskFact
中科院分区：
文献类型：
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作者：
Madjedi,KianM;Stuart,KelseyV;Chua,SharonYL;Ramulu,PradeepY;Warwick,Alasdair;Luben,RobertN;Sun,Zihan;Chia,MarkA;Aschard,Hugues;Wiggs,JaneyL;Kang,JaeH;Pasquale,LouisR;Foster,PaulJ;Khawaja,AnthonyP;ModifiableRiskFact
目的研究体力活动（PA）与青光眼及相关性状的关系，评估青光眼的遗传易感性是否改变了这些关系，并使用孟德尔随机化（MR）方法探讨因果关系。使用来自大型遗传联合体的汇总统计量的双样本MR实验。具有自我报告或加速度计得出的PA和眼内压数据的英国生物样本库参与者（IOP; n = 94 206和n = 27 777），黄斑内视网膜OCT测量（分别为n = 36 274和n = 9991）和青光眼状态（n = 86 803和n = 23 556，方法我们评估了自我报告的多变量调整后的关联，（国际体力活动问卷）和加速度计衍生的PA与IOP和黄斑内视网膜OCT参数使用线性回归和青光眼状态使用逻辑回归。对于所有结果，我们使用多基因风险评分（PRS）检查基因-PA相互作用，该评分结合了与青光眼相关的2673种遗传变异的影响。主要结果测量眼内压、黄斑视网膜神经纤维层（mRNFL）厚度、黄斑神经节细胞-内丛状层（mGCIPL）厚度和青光眼状态。我们发现PA水平或PA时间与青光眼状态无关。较高的总体水平和花费在较高水平的自我报告和加速度计衍生的PA的时间更长与较厚的mGCIPL呈正相关（每个趋势的P< 0.001）。与PA的最低四分位数相比，加速度计得出的中等强度和高强度PA的最高四分位数的参与者显示出+0.57 μm（P< 0.001）和+0.42 μm（P= 0.005）的mGCIPL。未发现与mRNFL厚度相关。自我报告的PA总体水平较高与IOP适度升高（+0.08 mmHg）相关（P= 0.01），但这在加速度计数据中未重复。没有协会被修改的青光眼PRS，MR分析不支持PA和任何青光眼相关outcome.ConclusionsHigher整体PA水平和更大的时间花费在中度和剧烈PA之间的因果关系与青光眼状态，但与较厚的mGCIPL。与IOP的相关性是适度和不一致的。尽管有充分的证据证明PA后IOP的急性降低，但我们没有发现任何证据表明高水平的习惯性PA与青光眼状态或普通人群的IOP相关。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。
PurposeTo examine the association of physical activity (PA) with glaucoma and related traits, to assess whether genetic predisposition to glaucoma modified these associations, and to probe causal relationships using Mendelian randomization (MR).DesignCross-sectional observational and gene–environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia.ParticipantsUK Biobank participants with data on self-reported or accelerometer-derived PA and intraocular pressure (IOP; n = 94 206 and n = 27 777, respectively), macular inner retinal OCT measurements (n = 36 274 and n = 9991, respectively), and glaucoma status (n = 86 803 and n = 23 556, respectively).MethodsWe evaluated multivariable-adjusted associations of self-reported (International Physical Activity Questionnaire) and accelerometer-derived PA with IOP and macular inner retinal OCT parameters using linear regression and with glaucoma status using logistic regression. For all outcomes, we examined gene–PA interactions using a polygenic risk score (PRS) that combined the effects of 2673 genetic variants associated with glaucoma.Main Outcome MeasuresIntraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell–inner plexiform layer (mGCIPL) thickness, and glaucoma status.ResultsIn multivariable-adjusted regression models, we found no association of PA level or time spent in PA with glaucoma status. Higher overall levels and greater time spent in higher levels of both self-reported and accelerometer-derived PA were associated positively with thicker mGCIPL (P< 0.001 for trend for each). Compared with the lowest quartile of PA, participants in the highest quartiles of accelerometer-derived moderate- and vigorous-intensity PA showed a thicker mGCIPL by +0.57 μm (P< 0.001) and +0.42 μm (P= 0.005). No association was found with mRNFL thickness. High overall level of self-reported PA was associated with a modestly higher IOP of +0.08 mmHg (P= 0.01), but this was not replicated in the accelerometry data. No associations were modified by a glaucoma PRS, and MR analyses did not support a causal relationship between PA and any glaucoma-related outcome.ConclusionsHigher overall PA level and greater time spent in moderate and vigorous PA were not associated with glaucoma status but were associated with thicker mGCIPL. Associations with IOP were modest and inconsistent. Despite the well-documented acute reduction in IOP after PA, we found no evidence that high levels of habitual PA are associated with glaucoma status or IOP in the general population.Financial Disclosure(s)Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.