Blood lead concentration and children's anthropometric dimensions in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994
Blood lead concentration and children's anthropometric dimensions in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994
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DOI：
10.1016/s0022-3476(99)70250-7
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发表时间：
1999-05-01
影响因子：
5.1
通讯作者：
Gunter, EW
中科院分区：
文献类型：
--
作者：
Ballew, C;Khan, LK;Gunter, EW
目的：评估铅暴露与儿童体格发育之间的关系。设计：1988- 1994年第三次全国健康和营养检查调查数据的横断面分析。参与者：共4391名非西班牙裔白色、非西班牙裔黑人和墨西哥裔美国儿童，年龄1 - 7岁。测量和结果：我们研究了血铅浓度与身高、头围、体重和体重指数之间的关系，并采用多元回归分析调整了性别、种族、铁状况、饮食摄入、病史、社会人口学因素，和家庭特征。血铅浓度与身高、头围呈显著负相关。回归模型预测，血铅浓度每增加0.48 μ mol/L（10 μ g/dL），身高减少1.57 cm，头围减少0.52 cm。我们没有发现血铅浓度与体重或体重指数之间存在显著相关性。1 - 7岁儿童血铅浓度与身高和头围之间的显著负相关，与1976-1980年第二次全国健康和营养检查调查报告的相关程度相似，这表明，尽管美国儿童的平均血铅浓度已经下降了20年，但铅暴露可能会继续影响一些儿童的生长。
Objective: To assess the association between lead exposure and children's physical growth.Design: Cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey, 1988-1994.Participants: A total of 4391 non-Hispanic white, non-Hispanic black, and Mexican-American children age 1 to 7 years.Measurements and Results: We investigated the association between blood lead concentration and stature, head circumference, weight, and body mass index with multiple regression analysis adjusting for sex, ethnic group, iron status, dietary intake, medical history, sociodemographic factors, and household characteristics. Blood lead concentration was significantly negatively associated with stature and head circumference. Regression models predicted reductions of 1.57 cm in stature and 0.52 cm in head circumference for each 0.48 mu mol/L (10 mu g/dL) increase in blood lead concentration. We did not find significant associations between blood lead concentration and weight or body mass index.Conclusions: The significant negative associations between blood lead concentration and stature and head circumference among children age 1 through 7 years, similar in magnitude to those reported for the Second National Health and Nutrition Examination Survey, 1976-1980, suggest that although mean blood lead concentrations of children have been declining in the United States for 2 decades, lead exposure may continue to affect the growth of some children.