Synaptic depolarization is more effective than back-propagating action potentials during induction of associative long-term potentiation in hippocampal pyramidal neurons.
Synaptic depolarization is more effective than back-propagating action potentials during induction of associative long-term potentiation in hippocampal pyramidal neurons.
复制标题
DOI：
10.1523/jneurosci.6000-08.2009
复制
发表时间：
2009-03-11
期刊：
影响因子：
--
通讯作者：
Spruston N
中科院分区：
文献类型：
--
作者：
Hardie J;Spruston N
长时程增强（LTP）需要突触后去极化，这可能是由与动作电位配对的EPSP或触发树突棘的更大EPSP引起的。我们探讨了在海马CA 1区锥体神经元突触驱动动作电位放电过程中，这些去极化源对LTP诱导的相对贡献。当弱输入和强输入都位于顶树突时，弱输入与强输入的配对导致大的LTP（~75%增加）。这种形式的LTP不需要躯体动作电位。当强输入位于基底树突时，产生的LTP较小（增加≤25%）。将测试输入与体细胞诱发的动作电位配对模拟了这种形式的LTP。因此，反向传播动作电位可能有助于适度的LTP，但局部突触去极化和/或树突棘波介导更强形式的LTP，其需要相关突触输入的空间接近度。
Long-term potentiation (LTP) requires postsynaptic depolarization that can result from EPSPs paired with action potentials or larger EPSPs that trigger dendritic spikes. We explored the relative contribution of these sources of depolarization to LTP induction during synaptically driven action potential firing in hippocampal CA1 pyramidal neurons. Pairing of a weak test input with a strong input resulted in large LTP (~75% increase) when the weak and strong inputs were both located in the apical dendrites. This form of LTP did not require somatic action potentials. When the strong input was located in the basal dendrites, the resulting LTP was smaller (≤25% increase). Pairing the test input with somatically evoked action potentials mimicked this form of LTP. Thus, back-propagating action potentials may contribute to modest LTP, but local synaptic depolarization and/or dendritic spikes mediate a stronger form of LTP that requires spatial proximity of the associated synaptic inputs.