Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration
Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration
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DOI：
10.1016/j.bbrc.2007.12.183
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发表时间：
2008-03-14
影响因子：
3.1
通讯作者：
Kume, Tsutomu
中科院分区：
文献类型：
--
作者：
Hayashi, Hisaki;Kume, Tsutomu
Foxc1和Foxc2转录因子是血管发育所必需的。然而，Foxc1和Foxc2控制血管生成（从预先存在的血管和毛细血管生长新血管）的分子机制仍然未知。CXC趋化因子配体12（CXCL12）及其受体CXCR4在血管生成过程中起关键作用，包括内皮细胞的迁移和管形成。在这里，我们表明，Foxc1和Foxc2直接诱导CXCR4的表达，通过激活其启动子在内皮细胞。此外，Foxc1缺陷的内皮细胞显示CXCR4表达以及CXCL12刺激的迁移显著减少。总之，这些结果提供了新的证据表明，Foxc转录因子是重要的调节因子的趋化运动的内皮细胞通过诱导CXCR4的表达。(C)2008年爱思唯尔公司All rights reserved.
Foxc1 and Foxc2 transcription factors are required for vascular development. However, the molecular mechanisms by which Foxcl and Foxc2 control angiogenesis, the growth of new blood vessels from pre-existing vessels and capillaries, remain unknown. CXC chemokine ligand 12 (CXCL12) and its receptor, CXCR4, are critical for the process of angiogenesis, including the migration and tube formation of endothelial cells. Here we show that Foxcl and Foxc2 directly induce CXCR4 expression by activating its promoter in endothelial cells. Furthermore, Foxc1-deficient endothelial cells show a significant reduction in CXCR4 expression as well as CXCL12-stimulated migration. Taken together, these results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. (C) 2008 Elsevier Inc. All rights reserved.