Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects
Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects
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DOI：
10.1002/mrm.20023
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发表时间：
2004-04-01
影响因子：
3.3
通讯作者：
Tofts, PS
中科院分区：
文献类型：
--
作者：
Parkes, LM;Rashid, W;Tofts, PS
在从临床脑血流灌注测量中得出有意义的结论之前，必须确定测量的精度，并在受试者之间和受试者内部变异性来源的背景下进行设置。本研究建立了使用无创MRI连续动脉自旋标记（CASL）技术进行灌注测量的可重复性。对34名健康正常人进行灌注测定。评估了受试者间的可变性，并估计了年龄和性别的贡献。受试者间差异很大，相同年龄和性别的受试者的灌注差异可达100%。同一受试者的重复测量表明，与受试者间差异和脑内大容量灌注变化相比，灌注在短期内保持显著稳定。灰质/白质灌注比随年龄增加而显著降低（每年0.79%）（P < 0.0005）。这似乎主要是由于灰质灌注减少，发现其每年减少0.45% （P = 0.04）。区域分析表明，与灰质年龄相关的变化主要集中在额叶皮层。女性的全脑灌注比男性高13% （P = 0.02）。(C) 2004 Wiley-Liss, Inc。
Before meaningful conclusions can be drawn from clinical measures of cerebral blood perfusion, the precision of the measurement must be determined and set in the context of inter- and intrasubject sources of variability. This work establishes the reproducibility of perfusion measurements using the noninvasive MRI technique of continuous arterial spin labeling (CASL). Perfusion was measured in 34 healthy normal subjects. Intersubject variability was assessed, and age and gender contributions were estimated. Intersubject variation was found to be large, with up to 100% perfusion difference for subjects of the same age and gender. Repeated measurements in one subject showed that perfusion remains remarkably stable in the short term when compared with intersubject variation and the large capacity for perfusion change in the brain. A significant decrease in the ratio of gray-matter to white-matter perfusion was found with increasing age (0.79% per year (P < 0.0005)). This appears to be due mainly to a reduction in gray-matter perfusion, which was found to decrease by 0.45% per year (P = 0.04). Regional analysis suggested that the gray-matter age-related changes were predominantly localized in the frontal cortex. Whole-brain perfusion was 13% higher (P = 0.02) in females compared to males. (C) 2004 Wiley-Liss, Inc.