Inflammation-sensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study
Inflammation-sensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study
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DOI：
10.1016/j.atherosclerosis.2008.05.038
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发表时间：
2009-02-01
期刊：
影响因子：
5.3
通讯作者：
Lindgarde, Folke
中科院分区：
文献类型：
--
作者：
Engstrom, Gunnar;Hedblad, Bo;Lindgarde, Folke
背景资料：虽然炎症与不同的心血管疾病有关，但与未来心力衰竭（HF）的关系尚不清楚。这项基于人群的研究探讨了血浆炎症蛋白水平升高是否与HE发病率相关。方法：在6071名无心肌梗死（MI）或卒中史的男性（平均年龄46岁）中测定了5种炎症敏感血浆蛋白（ISP、纤维蛋白原、铜蓝蛋白、触珠蛋白、类粘蛋白和α 1-抗胰蛋白酶）。在22年的随访中监测了因HF（初步诊断）住院的发生率，与ISP升高的数量（即，在第四个四分位数）。受试者在随访期间与心肌梗死censored.Results：在后续提示，159名男子住院，由于HE所有ISP的基线水平，除了结合珠蛋白，显着高于男性谁发展HE调整后的混杂因素，HF的风险比（HR）为1.00（参考），1.7（95% CI：1.1-2.7），2.0（CI：1.2-3.3）和2.6（CI：1.6-4.1），在第四四分位数中没有、有1个、2个和3个或更多ISP的男性中分别为1.7（95% CI：1.1 - 2.7），2.0（CI：1.2 - 3.3）和2.6（CI：1.6-4.1）（趋势：p
Background: Although inflammation has been associated with different cardiovascular diseases, the relationships with future heart failure (HF) are unclear. This population-based study explored whether elevated plasma levels of inflammatory proteins are associated with incidence of HEMethods: Five inflammation-sensitive plasma proteins (ISPs, fibrinogen, ceruloplasmin, haptoglobin, orosomucoid, and alpha 1-antitrypsin) was measured in 6071 men (mean age 46 years) without history of myocardial infarction (MI) or stroke. Incidence of hospitalizations due to HF (primary diagnosis) was monitored over 22 years of follow-up, in relation to the number of elevated ISPs (i.e., in the 4th quartile). Subjects with myocardial infarction during follow-up were censored.Results: During the follow-tip, 159 men were hospitalized due to HE Baseline levels of all ISPs, except for haptoglobin, were significantly higher in men who developed HE After adjustments for confounding factors, the hazard ratios (HR) of HF were 1.00 (reference), 1.7 (95% CI: 1.1-2.7), 2.0 (CI: 1.2-3.3) and 2.6 (CI: 1.6-4.1), respectively, in men with none, one, two and three or more ISPs in the 4th quartile (trend: p