Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise
Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise
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DOI：
10.1249/mss.0b013e3181923957
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发表时间：
2009-05-01
期刊：
影响因子：
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通讯作者：
Green, Daniel J.
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文献类型：
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作者：
Thijssen, Dick H. J.;Dawson, Ellen A.;Green, Daniel J.
THIJSSEN、D. H. J.、E. A. DAWSON、M. A. BLACK、M. T. E. 霍普曼、N. T. 电缆。和D.J.格林。肱动脉血流对不同下肢运动方式的反应。医学。科学。体育锻炼，卷。 41，第 5 期，第 1072-1079 页，2009 年。简介/目的：骑自行车与不活动上肢的肱动脉 (BA) 中可重复的收缩期顺行和舒张期逆行血流模式相关，从而导致内皮一氧化氮 (NO) 释放。本研究的目的是探讨不同类型和强度的下肢运动油对 BA 血流模式的影响。方法：我们检查了 12 名年轻受试者（24 +/- 3 岁）在骑自行车、踢腿和步行运动期间的 BA 血流和剪切率模式。在基线（1 分钟）和骑车（60、80 和 120 W）、双腿踢（5、7.5 和 10 kg）和步行（3、4 和 5 km.h(-1)）三个增量强度水平（每次 3 分钟）评估 BA 直径、血流量和剪切率。高分辨率 B 型动脉超声图像的边缘检测和壁跟踪，结合同步多普勒波形包络分析，可连续计算导管动脉直径以及整个心动周期的顺行/逆行血流量和剪切率。结果：在每个运动方案中，BA 平均血流量和剪切率显着增加（P < 0.001），并且在每个方案中，BA 顺行血流量和剪切率显示出可比的增加（P < 0.001）。然而，逆行血流和剪切率在骑自行车和步行期间显着增加（P < 0.001），但在踢腿期间则没有显着增加。结论：有节律的下肢运动（骑自行车和步行）导致 BA 收缩期顺行血流和剪切率增加，随后直接出现较大的逆行血流和剪切率。这种典型的模式以前与内皮一氧化氮释放有关，但在不同类型的运动（例如踢腿）中并不存在。
THIJSSEN, D. H. J., E. A. DAWSON, M. A. BLACK, M. T. E. HOPMAN, N. T. CABLE. and D. J. GREEN. Brachial Artery Blood Flow Responses to Different Modalities of Lower Limb Exercise. Med. Sci. Sports Exerc., Vol. 41, No. 5, pp. 1072-1079, 2009. Introduction/Purpose: Cycling is associated with a reproducible systolic anterograde and diastolic retrograde flow pattern in the brachial artery (BA) of the inactive upper limb, which results in endothelial nitric oxide (NO) release. The purpose of this study was to examine the impact of different types and intensities of lower limb exercise oil the BA flow pattern. Methods: We examined BA blood flow and shear rate patterns during cycling, leg kicking, and walking exercise in 12 young subjects (24 +/- 3 yr). BA diameter, blood flow, and shear rate were assessed at baseline (1 min) and at three incremental intensity levels of cycling (60, 80, and 120 W), bilateral leg kicking (5, 7.5, and 10 kg), and walking (3, 4, and 5 km.h(-1)), performed for 3 min each. Edge detection and wall tracking of high-resolution B-mode arterial ultrasound images, combined with synchronized Doppler waveform envelope analysis, were used to calculate conduit artery diameter and anterograde/retrograde blood flow and shear rate continuously across the cardiac cycle. Results: BA mean blood flow and shear rate increased significantly throughout each exercise protocol (P < 0.001), and BA anterograde blood flow and shear rate showed comparable increases throughout each protocol (P < 0.001). Retrograde blood flow and shear rate, however, demonstrated a significant increase during cycling and walking (P < 0.001) but not during leg kicking. Conclusion: Rhythmic lower limb exercise (cycling and walking) results in an increase in BA systolic anterograde blood flow and shear rate, directly followed by a large retrograde flow and shear rate. This typical pattern, previously linked with endothelial NO release, is not present during a different type of exercise such as leg kicking.