Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus.
Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus.
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DOI：
10.1038/srep29909
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发表时间：
2016-07-25
影响因子：
4.6
通讯作者：
Morand EF
中科院分区：
文献类型：
--
作者：
Connelly KL;Kandane-Rathnayake R;Hoi A;Nikpour M;Morand EF
种族是影响SLE疾病严重程度的关键因素，但这些关联的分子机制尚不清楚。I型IFN和MIF均与SLE发病机制相关。我们调查了亚洲患者SLE严重程度的增加是否与MIF或I型IFN相关。SLE患者（n = 151）对疾病变量进行前瞻性记录。测定血清MIF和三种I型ifn诱导的趋化因子（IFNCK:CCL2, CXCL10, CCL19）的综合评分。评估MIF和IFNCK评分与疾病活动性的关联，在中位随访2.6年期间，持续活动性疾病（PAD）被用作高疾病活动性的标志。在单变量分析中，MIF、IFNCK评分和亚洲种族与PAD显著相关。亚洲种族与较高的MIF有关，但与IFNCK评分无关。在多变量logistic回归分析中，MIF （OR3.62 (95% CI 1.14,11.5), p = 0.03）和亚洲种族（OR3.00 (95% CI 1.39,6.46), p < 0.01）与PAD显著相关，但IFNCK与PAD无关。这些结果可能支持MIF，而不是I型IFN在亚洲SLE患者SLE疾病严重程度升高中的作用。MIF和亚裔与PAD的关联至少部分是独立的。
Ethnicity is a key factor impacting on disease severity in SLE, but molecular mechanisms of these associations are unknown. Type I IFN and MIF have each been associated with SLE pathogenesis. We investigated whether increased SLE severity in Asian patients is associated with either MIF or Type I IFN. SLE patients (n = 151) had prospective recording of disease variables. Serum MIF, and a validated composite score of three Type I IFN-inducible chemokines (IFNCK:CCL2, CXCL10, CCL19) were measured. Associations of MIF and IFNCK score with disease activity were assessed, with persistent active disease (PAD) used as a marker of high disease activity over a median 2.6 years follow up. In univariable analysis, MIF, IFNCK score and Asian ethnicity were significantly associated with PAD. Asian ethnicity was associated with higher MIF but not IFNCK score. In multivariable logistic regression analysis, MIF (OR3.62 (95% CI 1.14,11.5), p = 0.03) and Asian ethnicity (OR3.00 (95% CI 1.39,6.46), p < 0.01) but not IFNCK were significantly associated with PAD. These results potentially support an effect of MIF, but not Type I IFN, in heightened SLE disease severity in Asian SLE. The associations of MIF and Asian ethnicity with PAD are at least partly independent.