MAGNETIC-FIELD DEPENDENCE OF SOLVENT PROTON RELAXATION INDUCED BY GD3+ AND MN2+ COMPLEXES
MAGNETIC-FIELD DEPENDENCE OF SOLVENT PROTON RELAXATION INDUCED BY GD3+ AND MN2+ COMPLEXES
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DOI：
10.1002/mrm.1910010408
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
BROWN, RD
中科院分区：
文献类型：
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作者：
KOENIG, SH;BAGLIN, C;BROWN, RD
溶质顺磁离子对溶剂水质子纵向磁弛豫速率1/T1的影响取决于磁场强度和离子的化学环境。测量了Gd3+和Mn2+离子溶液在三种不同的生理pH附近环境中的1/T1随场的变化：水合水离子；被EDTA(乙二胺四乙酸)和DTPA(二乙三胺五乙酸)络合；以及与刀豆蛋白A结合。结果表明，在目前进行核磁共振成像的电场范围内，化学环境可以改变溶剂质子的1/T1超过一个数量级。讨论了这些结果与这些离子作为增强核磁共振图像对比度的试剂的潜在用途的相关性。
The effect of solute paramagnetic ions on the longitudinal magnetic relaxation rate 1/T1of solvent water protons depends on magnetic field strength and on the chemical environment of the ions. The variation of 1/T1with field has been measured for solutions of Gd3+and Mn2+ions in three grossly different environments near physiological pH: the hydrated aquoion; chelated by EDTA (ethylenediaminetetraacetic acid) and DTPA (diethylenetriaminepentaacetic acid); and bound to the protein concanavalin A. It is demonstrated that over the field range at which NMR imaging is currently being done, the chemical environment can alter 1/T1of solvent protons by more than an order of magnitude. The relevance of these results to the potential utility of these ions as agents for enhancement of contrast in NMR images is discussed.