Brain processing of the signals ascending through unmyelinated C fibers in humans: An event-related functional magnetic resonance imaging study
Brain processing of the signals ascending through unmyelinated C fibers in humans: An event-related functional magnetic resonance imaging study
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DOI：
10.1093/cercor/bhj071
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发表时间：
2006-09-01
期刊：
影响因子：
3.7
通讯作者：
Kakigi, Ryusuke
中科院分区：
文献类型：
--
作者：
Qiu, Yunhai;Noguchi, Yasuki;Kakigi, Ryusuke
采用事件相关功能磁共振成像（Event-related functional magnetic resonance imaging，FMRI）研究了人类右手相位激光刺激诱发的外周C和A δ纤维上行信号的脑处理过程。C和A δ伤害感受器的刺激激活双侧丘脑、双侧次级体感皮层、右侧（同侧）中丘脑和双侧Brodmann区（BA）24/32，其中大部分活动位于前扣带皮层（ACC）的后部。然而，在右侧（同侧）BA 32/8/6，包括背侧部分在前部分的ACC（aACC）和前补充运动区（pre-SMA），和双侧前额叶皮层的活动幅度是显着强于A δ伤害性感受器的刺激后，C伤害性感受器。得出的结论是，与第二次疼痛相关的C伤害感受器的激活引起与A δ伤害感受器不同的大脑处理，与第一次疼痛相关，可能是由于两种疼痛的情感和动机方面的差异，这主要与aACC，前SMA和前额叶皮层有关。
Event-related functional magnetic resonance imaging was used to investigate brain processing of the signals ascending from peripheral C and A delta fibers evoked by phasic laser stimuli on the right hand in humans. The stimulation of both C and A delta nociceptors activated the bilateral thalamus, bilateral secondary somatosensory cortex, right (ipsilateral) middle insula, and bilateral Brodmann's area (BA) 24/32, with the majority of activity found in the posterior portion of the anterior cingulate cortex (ACC). However, magnitude of activity in the right (ipsilateral) BA32/8/6, including dorsal parts in the anterior portion of the ACC (aACC) and pre-supplementary motor area (pre-SMA), and the bilateral anterior insula was significantly stronger following the stimulation of C nociceptors than A delta nociceptors. It was concluded that the activation of C nociceptors, related to second pain, evokes different brain processing from that of A delta nociceptors, related to first pain, probably due to the differences in the emotional and motivational aspects of either pain, which are mainly related to the aACC, pre-SMA, and anterior insula.