Parental age as a risk factor of childhood leukemia and brain cancer in offspring
Parental age as a risk factor of childhood leukemia and brain cancer in offspring
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DOI：
10.1097/00001648-199905000-00014
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发表时间：
1999-05-01
期刊：
影响因子：
5.4
通讯作者：
Vaittinen, P
中科院分区：
文献类型：
--
作者：
Hemminki, K;Kyyrönen, P;Vaittinen, P
我们在这里使用瑞典家庭癌症数据库，以分析1960年至1994年之间的儿童白血病和脑癌的时间趋势，以及父母年龄对儿童白血病和脑癌的影响，每个约1500例。该数据库包括1940年以后在瑞典出生的所有人及其亲生父母，超过600万人，其癌症是从1958年至1994年的瑞典癌症登记处检索的。从1960年到1994年，癌症发病率增加;低级别星形细胞瘤占大多数，而高级别星形细胞瘤的发病率没有增加。到1980年左右，白血病有适度的增加。我们发现白血病和脑癌的父母年龄效应，前者（在35岁以上的人中超过50%）由母亲年龄介导，后者（超过25%）由父亲年龄介导。生殖细胞成熟过程中染色体畸变和突变的积累是这些发现的可能机制。他们可以帮助部分解释这些恶性肿瘤的长期趋势和受过良好教育的后代的过度风险。
We use here the Swedish Family-Cancer Database to analyze the time trends in childhood leukemia and brain cancer between 1960 and 1994 and the effect of parental age on childhood leukemia and brain cancer of some 1500 cases each. The database includes all persons born in Sweden after 1940 with their biological parents, over 6 million individuals, whose cancers were retrieved from the Swedish Cancer Registry from years 1958-1994. incidence in cancer increased from 1960 to 1994; low grade astrocytoma accounted for most of the increase, whereas high grade astrocytoma has not increased in incidence. There has been a moderate increase in leukemia to about 1980. We found a parental age effect for both leukemia and brain cancer, with the former (of about 50% excess in those over 35 years) being mediated by maternal age and the latter (of about 25% excess) by paternal age. Accumulation of chromosomal aberrations and mutations during the maturation of germ cells is a likely mechanism for these findings. They can help to explain partially the secular trends of these malignancies and the excess risks in offspring of the well educated.