A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
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DOI：
10.1016/s0968-0004(03)00092-6
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发表时间：
2003-06-01
影响因子：
13.8
通讯作者：
Hegde, AN
中科院分区：
文献类型：
--
作者：
Upadhya, SC;Hegde, AN
帕金蛋白和其他不相关的蛋白质含有一个泛素样结构域（UbLD）。本文描述了一个基序，可能是重要的相互作用的UbLD含蛋白质（UbLPs）与蛋白酶体。蛋白酶体相互作用基序，这是保守的一个子集的UbLP，如parkin，Rad23和几个转录因子，可能使UbLP与蛋白酶体形成复合物的蛋白水解或最近发现的非蛋白水解功能的蛋白酶体。
Parkin and other unrelated proteins contain a ubiquitin-like domain (UbLD). This article describes a motif that might be important in the interaction of UbLD-containing proteins (UbLPs) with the proteasome. The proteasome-interacting motif, which is conserved in a subset of UbLPs, such as parkin, Rad23 and several transcription factors, is likely to enable the UbLPs to form a complex with the proteasome for proteolysis or the recently discovered non-proteolytic functions of the proteasome.