Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis.
Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis.
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膳食补充海洋鱼油对类风湿性关节炎白细胞脂质介质生成和功能的影响。
DOI：
10.1002/art.1780300905
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发表时间：
1987
影响因子：
--
通讯作者：
Robinson,DR
中科院分区：
文献类型：
--
作者：
Sperling,RI;Weinblatt,M;Robin,JL;Ravalese3rd,J;Hoover,RL;House,F;Coblyn,JS;Fraser,PA;Spur,BW;Robinson,DR
12名患有活动性类风湿关节炎的患者在日常饮食中补充20克Max - EPA鱼油，每天服用，持续6周。补充后，患者中性粒细胞细胞脂质中花生四烯酸与二十碳五烯酸的比例从81:1降至2.7:1，白三烯B4（钙离子载体刺激）的平均生成量显著下降33%。中性粒细胞对白三烯b4和FMLP的平均趋化性在第6周向正常范围显著增加。由钙离子载体刺激的单核细胞产生的5‐脂氧合酶产物没有被显著抑制，但血小板活化因子的产生在第6周显著下降（37%）。这些白细胞炎症电位的调节表明鱼油补充剂可能具有抗炎作用。
Twelve patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of Max‐EPA fish oil, daily, for 6 weeks. Following this supplementation, the ratio of arachidonic acid to eicosapentaenoic acid in the patients' neutrophil cellular lipids decreased from 81:1 to 2.7:1, and the mean generation of leukotriene B4(with calcium ionophore stimulation) significantly declined by 33%. The mean neutrophil chemotaxis to both leukotriene B4and FMLP significantly increased toward the normal range at week 6. The generation of 5‐lipoxygenase products by calcium ionophore‐stimulated monocytes was not significantly suppressed, but a significant decline (37%) in plateletactivating factor generation was noted at week 6. The modulation of these measures of leukocyte inflammatory potential suggests that fish oil supplementation may have an antiinflammatory effect.