Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer
Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer
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DOI：
10.7326/0003-4819-133-6-200009190-00008
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发表时间：
2000-09-19
影响因子：
39.2
通讯作者：
Sorensen, TIA
中科院分区：
文献类型：
--
作者：
Gronbæk, M;Becker, U;Sorensen, TIA
背景资料：虽然酒精摄入量和死亡率之间的J型关系已经在许多大型队列研究中重现，但啤酒、葡萄酒和烈酒的影响是否不同的问题仍然存在争议。教育水平;体力活动;和身体质量指数进行了评估，在基线。设置：哥本哈根，丹麦。参与者：13 064名男性和11 459名女性20至98岁。测量：死亡人数和死亡时间的所有原因，冠心病，癌症在following.Results：在257 859人年的后续行动，4833名参与者死亡。在不同葡萄酒摄入水平下，总酒精摄入量与死亡率之间存在J形关系。与不饮酒者相比，避免饮酒的轻度饮酒者因各种原因死亡的相对风险为0.90（95%CI，0.82至0.99），而饮酒者的相对风险为0.66（CI，0.55至0.77）。避免饮酒的重度饮酒者死于各种原因的风险高于那些将葡萄酒纳入酒精摄入量的重度饮酒者。饮酒者冠心病和癌症的死亡率显著低于不饮酒者（P = 0.007和P = 0.004，respectively）。结论：葡萄酒摄入量可能对全因死亡率有有益影响，这是酒精的添加剂。这种效果可能是由于减少了冠心病和癌症的死亡。
Background: Although the J-shaped relation between alcohol intake and mortality has been reproduced in many large cohort studies, the question of whether the effects of beer, wine, and spirits differ remains controversial.Objective: To examine the relation between intake of different types of alcohol and death from all causes, coronary heart disease, and cancer.Design: Pooled cohort studies in which intake of beer, wine, and spirits; smoking status; educational level; physical activity; and body mass index were assessed at baseline.Setting: Copenhagen, Denmark.Participants: 13 064 men and 11 459 women 20 to 98 years of age.Measurements: Number of deaths and time to death from all causes, coronary heart disease, and cancer during follow-up.Results: During 257 859 person-years of follow-up, 4833 participants died. J-shaped relations were found between total alcohol intake and mortality at various levels of wine intake. Compared with nondrinken, light drinkers who avoided wine had a relative risk for death from all causes of 0.90 (95% CI, 0.82 to 0.99) and those who drank wine had a relative risk of 0.66 (CI, 0.55 to 0.77). Heavy drinkers who avoided wine were at higher risk for death from all causes than were heavy drinkers who included wine in their alcohol intake. Wine drinkers had significantly lower mortality from both coronary heart disease and cancer than did non-wine drinkers (P = 0.007 and P = 0.004, respectively).Conclusion: Wine intake may have a beneficial effect on all-cause mortality that is additive to that of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer.