An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery
An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery
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DOI：
10.1002/cnm.2952
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发表时间：
2018-04-01
影响因子：
2.1
通讯作者：
Cai, Xiao-Chuan
中科院分区：
文献类型：
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作者：
Kong, Fande;Kheyfets, Vitaly;Cai, Xiao-Chuan
肺动脉中血流的模拟通过检查一些连续度量之间的关系提供了对某些疾病的一些见解，例如，作用于血管内皮的壁剪切应力，其通过释放血管舒张剂/收缩剂来响应流动诱导的机械力。V. Kheyoung在他以前的工作中，对患者特异性肺循环进行了数值研究，以表明壁剪切应力的降低与肺血管阻抗的增加相关。在本文中，我们开发了一个可扩展的并行算法的基础上，区域分解方法，以调查与患者特定的脉动波形作为入口边界条件的非定常模型。非定常模型提供了关于流场动态行为的更多信息，但从计算上讲，模拟要昂贵得多，因为与稳态问题类似的问题必须多次求解，因此，传统的顺序方法不再适用。我们计算表明，使用建议的并行方法与多达10000个处理器内核的模拟可以得到大大减少计算时间。这使得该技术潜在地可用于肺动脉中血流的动态行为的常规研究，特别是血流和壁切应力在空间和时间维度上的变化。
Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, eg, the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. V. Kheyfets, in his previous work, studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. In this paper, we develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient-specific pulsatile waveforms as the inlet boundary condition. The unsteady model offers tremendously more information about the dynamic behavior of the flow field, but computationally speaking, the simulation is a lot more expensive since a problem which is similar to the steady-state problem has to be solved many times, and therefore, the traditional sequential approach is not suitable anymore. We show computationally that simulations using the proposed parallel approach with up to 10000 processor cores can be obtained with much reduced compute time. This makes the technology potentially usable for the routine study of the dynamic behavior of blood flows in the pulmonary artery, in particular, the changes of the blood flows and the wall shear stress in the spatial and temporal dimensions.