2 DISTINCT TL-LIKE MOLECULAR SUBSETS DEFINED BY MONOCLONAL-ANTIBODIES ON THE SURFACE OF HUMAN THYMOCYTES WITH DIFFERENT EXPRESSION ON LEUKEMIA LINES
2 DISTINCT TL-LIKE MOLECULAR SUBSETS DEFINED BY MONOCLONAL-ANTIBODIES ON THE SURFACE OF HUMAN THYMOCYTES WITH DIFFERENT EXPRESSION ON LEUKEMIA LINES
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DOI：
10.1007/bf00364207
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发表时间：
1984-01-01
期刊：
影响因子：
3.2
通讯作者：
MAWAS, C
中科院分区：
文献类型：
--
作者：
OLIVE, D;DUBREUIL, P;MAWAS, C
在人胸腺细胞和一些T白血病细胞系表面表达的与tl样I类抗原反应的单克隆抗体被发现定义了3个独立的表位簇，其中2个可以通过固相放射免疫测定和顺序免疫沉淀显示存在于血清学上不同的分子亚群上。这两个分子亚群都由一个与。β相关的49-K H链组成。-2微球蛋白L链。胸腺细胞表达这两种分子亚群的数量相似，而在T白血病细胞系中，这两种分子亚群的数量因细胞系而异。
Monoclonal antibodies reacting TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define 3 independent epitopic clusters, 2 of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by sequential immunoprecipitation. Both molecular subsets consist of a 49-K H chain associated with a .beta.-2 microglobulin L chain. Thymocytes expressed similar amounts of the 2 molecular subsets, while on T leukemia lines the amount of these 2 molecular subsets varied from line to line.