RESTORATION OF COLLAGEN FORMATION IN PHOTODAMAGED HUMAN SKIN BY TRETINOIN (RETINOIC ACID)
RESTORATION OF COLLAGEN FORMATION IN PHOTODAMAGED HUMAN SKIN BY TRETINOIN (RETINOIC ACID)
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DOI：
10.1056/nejm199308193290803
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发表时间：
1993-08-19
影响因子：
158.5
通讯作者：
VOORHEES, JJ
中科院分区：
文献类型：
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作者：
GRIFFITHS, CEM;RUSSMAN, AN;VOORHEES, JJ
背景。外用维A酸（视黄酸）可以改善因暴露在阳光下而受损的人类皮肤的细纹和某些其他特征（光损伤），但组织学变化并不能解释这种改善。在紫外线引起光损伤的小鼠中，维A酸消除细纹与真皮胶原蛋白合成相关，但与组织学变化无关。我们研究了光损伤的人类皮肤中胶原蛋白合成是否减少，如果是，是否可以通过局部维A酸治疗来恢复。方法。对 26 名健康受试者进行了前臂伸肌侧光损伤皮肤和避免阳光照射的臀部皮肤的活组织检查。此外，29 名皮肤光损伤患者每天使用 0.1% 维甲酸霜（15 名患者）或载体霜（14 名患者）接受治疗 10 至 12 个月。对基线和治疗后获得的皮肤活检标本进行免疫组织学评估，以获取真皮胶原蛋白 I 形成（胶原蛋白合成）的证据。结果。光损伤皮肤的乳头状真皮中 I 型胶原蛋白的形成比免受阳光照射的皮肤少 56%（P
Background. Topical tretinoin (retinoic acid) modifies fine wrinkles and certain other features of human skin damaged by exposure to the sun (photodamage), but histologic changes do not account for this improvement. In mice with photodamage induced by ultraviolet light, effacement of fine wrinkles by tretinoin is correlated with dermal collagen synthesis but not with histologic changes. We investigated whether collagen synthesis was reduced in photodamaged human skin and, if so, whether it could be restored by treatment with topical tretinoin.Methods. Biopsies of photodamaged skin from the extensor aspect of the forearm and skin from the buttocks, which had been protected from the sun, were performed on 26 healthy subjects. In addition, 29 patients with photodamaged skin were treated for 10 to 12 months with a daily application of 0.1 percent tretinoin cream (15 patients) or vehicle cream (14 patients). Skin-biopsy specimens obtained at base line and after treatment were assessed immunohistologically for evidence of dermal collagen I formation (collagen synthesis).Results. Collagen I formation was 56 percent less in the papillary dermis of photodamaged skin than in skin protected from the sun (P