Transgenic Drosophila models of Alzheimer's disease and tauopathies.
Transgenic Drosophila models of Alzheimer's disease and tauopathies.
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DOI：
10.1007/s00429-009-0234-4
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发表时间：
2010-03
影响因子：
3.1
通讯作者：
Iijima, Koichi
中科院分区：
文献类型：
--
作者：
Iijima-Ando, Kanae;Iijima, Koichi
阿尔茨海默病（AD）是最常见的老年痴呆症。淀粉样蛋白- β42肽（a - β42）和tau蛋白的聚集是AD大脑的病理标志。越来越多的证据表明，a β42在AD的发病机制中起核心作用，而tau在a β42的下游作为疾病进展的调节剂。在与17号染色体相关的帕金森病额颞叶痴呆（FTDP-17）和其他相关疾病（所谓的Tau病）中也观察到Tau病理。虽然大多数病例是散发的，但已经鉴定出与家族性AD和FTDP-17相关的基因，这导致了转基因动物模型的发展。果蝇一直是一个强大的遗传模型系统，用于生物学的许多领域，最近成为人类神经退行性疾病的模型。在这篇综述中，我们将总结转基因果蝇AD和牛头病模型的主要特征，以及这些模型对疾病机制和治疗意义的一些见解。
Alzheimer's disease (AD) is the most common form of senile dementia. Aggregation of the amyloid- β42 peptide (Aβ42) and tau proteins are pathological hallmarks in AD brains. Accumulating evidence suggests that Aβ42 plays a central role in the pathogenesis of AD, and tau acts downstream of Aβ42 as a modulator of the disease progression. Tau pathology is also observed in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases, so called tauopathies. Although most cases are sporadic, genes associated with familial AD and FTDP-17 have been identified, which led to the development of transgenic animal models. Drosophila has been a powerful genetic model system used in many fields of biology, and recently emerges as a model for human neurodegenerative diseases. In this review, we will summarize key features of transgenic Drosophila models of AD and tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from these models.
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