Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: A pathway-based analysis
Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: A pathway-based analysis
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DNA 修复基因和非小细胞肺癌生存的潜在功能多态性：基于通路的分析
DOI：
10.1002/mc.20819
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发表时间：
2012-07-01
影响因子：
4.6
通讯作者：
Shen, Hongbing
中科院分区：
文献类型：
--
作者：
Dong, Jing;Hu, Zhibin;Shen, Hongbing
为了系统地评估DNA修复基因的潜在功能多态性是否影响非小细胞肺癌（NSCLC）的临床行为，我们在568例肺癌患者的病例队列中研究了50个候选DNA修复基因的218个信号核苷酸多态性（SNP）对NSCLC总生存率的影响。与肺癌预后相关的SNPs主要定位于不同修复途径的14个基因，在多变量逐步考克斯回归分析后，6个SNPs保留在最终模型中：ATM rs 189037; MRE 11 A rs 11020802; ERCC 2 rs 1799793; MBD 4 rs 140693; XRCC 1 rs 25487和PMS 1 rs 5742933。在这6个SNP的联合分析中，不利基因座数量的增加与较差的预后相关（P趋势：
To assess systematically whether potentially functional polymorphisms in DNA repair genes influence the clinical behavior of non-small-cell lung cancer (NSCLC), we examined the impact of a comprehensive panel of 218 signal nucleotide polymorphisms (SNP) in 50 candidate DNA repair genes on overall survival of NSCLC in a case-cohort of 568 lung cancer patients. SNPs associated with lung cancer prognosis primarily mapped to 14 genes in different repair pathways, and 6 SNPs were remained in the final model after multivariate stepwise Cox regression analysis: ATM rs189037; MRE11A rs11020802; ERCC2 rs1799793; MBD4 rs140693; XRCC1 rs25487, and PMS1 rs5742933. In the combined analysis of these 6 SNPs, an increasing number of unfavorable loci was associated with a poorer prognosis (P for trend: