Individual Differences in Human Path Integration Abilities Correlate with Gray Matter Volume in Retrosplenial Cortex, Hippocampus, and Medial Prefrontal Cortex.
Individual Differences in Human Path Integration Abilities Correlate with Gray Matter Volume in Retrosplenial Cortex, Hippocampus, and Medial Prefrontal Cortex.
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DOI：
10.1523/eneuro.0346-16.2017
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发表时间：
2017-03
期刊：
影响因子：
3.4
通讯作者：
Stern CE
中科院分区：
文献类型：
--
作者：
Chrastil ER;Sherrill KR;Aselcioglu I;Hasselmo ME;Stern CE
人类的导航能力各不相同。这些个体差异的存在可能部分是因为成功的导航依赖于几种不同的能力，而这些能力依赖于不同的大脑结构。其中一种导航能力是路径整合，即位置和方向的更新，其中导航器在移动期间跟踪空间中的距离、方向和位置。虽然已经研究了与基于地标的导航相关的结构差异，但尚未测试与路径整合能力相关的灰质体积。在这里，我们研究了两个路径整合范式的个体差异：（1）位置跟踪任务和（2）任务跟踪平移和旋转的自我运动。使用基于体素的形态测量学，我们在这些路径整合任务中的表现差异相关的变化，在26个健康的年轻人的大脑形态。位置追踪任务的表现与路径整合的三个关键区域的灰质体积的个体差异呈正相关：海马、压后皮质和内侧前额叶皮质。这些地区是一致的路径整合系统已知的计算和动物模型，并提供了新的证据，形态学的变化，在压后和内侧前额叶皮层的基础上的个人差异，在人类路径整合能力。跟踪旋转自我运动的结果-而不是平移或位置-表明小脑灰质体积与个人表现相关。我们的研究结果还表明，路径整合的这三个方面在很大程度上是独立的。总之，这项研究的结果提供了一个链接个人能力和功能相关，计算模型，和动物模型的路径整合。
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures. One such navigational capability is path integration, the updating of position and orientation, in which navigators track distances, directions, and locations in space during movement. Although structural differences related to landmark-based navigation have been examined, gray matter volume related to path integration ability has not yet been tested. Here, we examined individual differences in two path integration paradigms: (1) a location tracking task and (2) a task tracking translational and rotational self-motion. Using voxel-based morphometry, we related differences in performance in these path integration tasks to variation in brain morphology in 26 healthy young adults. Performance in the location tracking task positively correlated with individual differences in gray matter volume in three areas critical for path integration: the hippocampus, the retrosplenial cortex, and the medial prefrontal cortex. These regions are consistent with the path integration system known from computational and animal models and provide novel evidence that morphological variability in retrosplenial and medial prefrontal cortices underlies individual differences in human path integration ability. The results for tracking rotational self-motion—but not translation or location—demonstrated that cerebellum gray matter volume correlated with individual performance. Our findings also suggest that these three aspects of path integration are largely independent. Together, the results of this study provide a link between individual abilities and the functional correlates, computational models, and animal models of path integration.