Comparison of Distribution- and Anchor-Based Approaches to Infer Changes in Health-Related Quality of Life of Prostate Cancer Survivors
Comparison of Distribution- and Anchor-Based Approaches to Infer Changes in Health-Related Quality of Life of Prostate Cancer Survivors
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DOI：
10.1111/j.1475-6773.2012.01395.x
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Chhatre, Sumedha
中科院分区：
文献类型：
--
作者：
Jayadevappa, Ravishankar;Malkowicz, Stanley Bruce;Chhatre, Sumedha
目的采用基于分布和锚点的方法确定一般和前列腺特异性健康相关生活质量（HRQoL）的最小重要差异（MID）。研究设计和设置前瞻性队列研究的602名新诊断的前列腺癌患者招募从城市学术医院和退伍军人管理局医院。参与者在基线和治疗后3、6、12和24个月完成了通用（SF-36）和前列腺特异性HRQoL调查。基于锚点和基于分布的方法用于开发MID估计值。我们比较了基于两种方法的MID估计值返回基线的参与者比例。结果SF-36各分量表的MID估计值分别为：身体功能= 7，身体角色= 14，情感角色= 12，活力= 9，心理健康= 6，社会功能= 9，身体疼痛= 9，一般健康= 8;前列腺特异性量表为泌尿功能= 8、肠功能= 7、性功能= 8、泌尿困扰= 9、肠困扰= 8和性困扰= 11。返回到基线值的参与者比例与两种方法的MID估计值相当。结论这是第一项使用基于锚点和基于分布的方法评估MID的通用和前列腺特异性HRQoL的研究。虽然这两种方法得出的MID估计值存在差异，但与这些估计值对应的回收率模式相当。
Objective To determine the minimal important difference (MID) in generic and prostate-specific health-related quality of life (HRQoL) using distribution- and anchor-based methods. Study Design and Setting Prospective cohort study of 602 newly diagnosed prostate cancer patients recruited from an urban academic hospital and a Veterans Administration hospital. Participants completed generic (SF-36) and prostate-specific HRQoL surveys at baseline and at 3, 6, 12, and 24 months posttreatment. Anchor-based and distribution-based methods were used to develop MID estimates. We compared the proportion of participants returning to baseline based on MID estimates from the two methods. Results MID estimates derived from combining distribution- and anchor-based methods for the SF-36 subscales are physical function = 7, role physical = 14, role emotional = 12, vitality = 9, mental health = 6, social function = 9, bodily pain = 9, and general health = 8; and for the prostate-specific scales are urinary function = 8, bowel function = 7, sexual function = 8, urinary bother = 9, bowel bother = 8, and sexual bother = 11. Proportions of participants returning to baseline values corresponding to MID estimates from the two methods were comparable. Conclusions This is the first study to assess the MID for generic and prostate-specific HRQoL using anchor-based and distribution-based methods. Although variation exists in the MID estimates derived from these two methods, the recovery patterns corresponding to these estimates were comparable.