Cortical circuitry mediating inter-areal touch signal amplification.
Cortical circuitry mediating inter-areal touch signal amplification.
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皮质电路介导区域间触摸信号放大。
DOI：
10.1101/2023.06.06.543886
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Peron,Simon
中科院分区：
文献类型：
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作者：
Ryan,Lauren;Sun-Yan,Andrew;Laughton,Maya;Peron,Simon
感觉皮层区域被组织成代表感觉上皮的地形图。区域间投影通常将跨区域的地形匹配的子区域连接起来。由于匹配的子区域处理相同的刺激，它们之间的相互作用是许多计算的中心。在这里，我们问的是，在主动触摸过程中，初级和次级触觉体感皮质(VS1和VS2)的地形匹配亚区是如何相互作用的。在触摸带有两个胡须的物体的小鼠的体积钙成像中，发现了稀疏的高响应性、宽调谐的触摸神经元，特别是在这两个区域的第二层。这些罕见的神经元表现出高度的同步性，并在两个方向上携带大多数触摸诱发活动。损毁任一区域对备用胡须做出反应的亚区会降低未损毁区域的触摸反应，而胡须特异的VS1损伤会降低胡须特异的VS2触摸反应。因此，稀疏的广泛调节的触摸神经元群在两个方向上主导着VS1-VS2的交流，并且地形匹配的VS1和VS2亚区反复放大胡须触摸活动。
Sensory cortical areas are organized into topographic maps representing the sensory epithelium. Interareal projections typically connect topographically matched subregions across areas. Because matched subregions process the same stimulus, their interaction is central to many computations. Here, we ask how topographically matched subregions of primary and secondary vibrissal somatosensory cortices (vS1 and vS2) interact during active touch. Volumetric calcium imaging in mice palpating an object with two whiskers revealed a sparse population of highly responsive, broadly tuned touch neurons especially pronounced in layer 2 of both areas. These rare neurons exhibited elevated synchrony and carried most touch-evoked activity in both directions. Lesioning the subregion of either area responding to the spared whiskers degraded touch responses in the unlesioned area, with whisker-specific vS1 lesions degrading whisker-specific vS2 touch responses. Thus, a sparse population of broadly tuned touch neurons dominates vS1-vS2 communication in both directions, and topographically matched vS1 and vS2 subregions recurrently amplify whisker touch activity.