Castration-Resistant Prostate Cancer: AUA Guideline Amendment
Castration-Resistant Prostate Cancer: AUA Guideline Amendment
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DOI：
10.1016/j.juro.2014.10.104
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发表时间：
2015-02-01
影响因子：
6.6
通讯作者：
Kibel, Adam S.
中科院分区：
文献类型：
--
作者：
Cookson, Michael S.;Lowrance, William T.;Kibel, Adam S.
目的：本次修订的目的是纳入相关的新发表的文献，以更好地提供一个合理的基础，去势抵抗性前列腺癌患者的管理。材料和方法：原始的系统评价和荟萃分析发表的文献产生了303篇文章，从1996年到2013年。这一审查构成了大多数准则声明。临床原则和专家意见用于缺乏足够循证数据的指南声明。2014年4月，根据第二次全面文献检索对CRPC指南进行了修订，检索到了2013年2月至2014年2月期间发表的其他研究。37项研究，从这个搜索提供的数据相关的具体治疗modelsfor CRPC.Results：指南声明的基础上开发的六个索引患者，以代表在临床实践中遇到的最常见的情况进行了适当的修改。补充文献为更新当前支持性文本以及纳入新的指导原则声明提供了基础。具体而言，镭-223被放置在有关CRPC.Conclusions治疗的指导方针：鉴于这一领域的快速发展的性质，这一指导方针应结合最近的系统性文献综述和理解个别患者的治疗目标。在选择管理策略时，应考虑患者的偏好和个人目标。新纳入的循证声明补充了2013年发布的原始指南，该指南为CRPC男性患者的治疗提供了指导。本指南将随着该领域新文献的出现而不断更新。
Purpose: The purpose of this amendment is to incorporate relevant newly-published literature to better provide a rational basis for the management of patients with castration-resistant prostate cancer.Materials and Methods: The original systematic review and meta-analysis of the published literature yielded 303 articles published from 1996 through 2013. This review formed a majority of the guideline statements. Clinical Principles and Expert Opinions were used for guideline statements lacking sufficient evidence-based data. In April 2014, the CRPC guideline underwent amendment based on a second comprehensive literature search, which retrieved additional studies published between February 2013 and February 2014. Thirty-seven studies from this search provided data relevant to the specific treatment modalities for CRPC.Results: Guideline statements based on six index patients developed to represent the most common scenarios encountered in clinical practice were amended appropriately. The additional literature provided the basis for an update of current supporting text as well as the incorporation of new guideline statements. Specifically, the addition of Radium-223 was placed in the guidelines related to the treatment of CRPC.Conclusions: Given the rapidly evolving nature of this field, this guideline should be used in conjunction with recent systematic literature reviews and an understanding of the individual patient's treatment goals. Patients' preferences and personal goals should be considered when choosing management strategies. The newly incorporated evidence-based statements supplement the original guideline published in 2013, which provided guidance for the treatment of men with CRPC. This guideline will be continually updated as new literature emerges in the field.