One pot synthesis of monodisperse water soluble iron oxide nanocrystals with high values of the specific absorption rate
One pot synthesis of monodisperse water soluble iron oxide nanocrystals with high values of the specific absorption rate
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DOI：
10.1039/c4tb00061g
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发表时间：
2014-01-01
影响因子：
7
通讯作者：
Pellegrino, Teresa
中科院分区：
文献类型：
--
作者：
Guardia, Pablo;Riedinger, Andreas;Pellegrino, Teresa
我们报道了一种高度可重复性的合成纳米氧化铁(IONPs)的方法，其尺寸和形状可控，尺寸分散度约为10%。通过调节合成中所用溶剂角鲨烷和二苯甲醚的相对比例，可以使颗粒的尺寸从14 nm变化到100 nm左右，而其形状则从立方体(尺寸到35 nm)演变为截断的八面体和八面体(尺寸从40 nm到100 nm)。通过改变加热坡道和铁前驱物与癸酸的比例，可以在每个范围内对粒度进行微调。我们还证明了合成的IONPs通过与没食子聚乙二醇分子的原位配体交换直接水转移，后者只需在70℃下加入到原始纳米晶混合物中。在患者认为安全的频率和外加磁场下，水转移IONPs的比吸收率(SAR)值证实了它们的高加热性能。最后，这种方法允许将35 nm纳米立方体作为单独包覆的稳定粒子转移到水相。首次研究了这种大尺寸IONPs的加热性能。这项工作揭示了在肿瘤治疗中使用大IONPs进行磁热治疗的可能性。
We report a highly reproducible route to synthesize iron oxide nanoparticles (IONPs) with control over size and shape and with size dispersions around 10%. By tuning the relative ratio of squalane to dibenzyl ether, which were used as solvents in the synthesis, the size of the particles could be varied from 14 to around 100 nm, while their shape evolved from cubic (for size ranges up to 35 nm) to truncated octahedra and octahedra (for sizes from 40 nm up to 100 nm). Fine tuning of the size within each of these ranges could be achieved by varying the heating ramp and the iron precursor to decanoic acid ratio. We also demonstrate direct water transfer of the as-synthesized IONPs via in situ ligand exchange with gallol polyethylene glycol molecules, the latter simply added to the crude nanocrystal mixture at 70 degrees C. The specific absorption rate (SAR) values measured on the water transferred IONPs, at frequencies and applied magnetic fields that are considered safe for patients, confirmed their high heating performance. Finally, this method allows the transfer of 35 nm nanocubes as individually coated and stable particles to the water phase. For the first time, the heating performance of such large IONPs has been studied. This work uncovers the possibility of using large IONPs for magnetic hyperthermia in tumor therapy.