Neuroanatomical correlates of pleasant and unpleasant emotion
Neuroanatomical correlates of pleasant and unpleasant emotion
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DOI：
10.1016/s0028-3932(97)00070-5
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发表时间：
1997-11-01
期刊：
影响因子：
2.6
通讯作者：
Schwartz, GE
中科院分区：
文献类型：
--
作者：
Lane, RD;Reiman, EM;Schwartz, GE
大量证据表明，人类情绪分类的一个关键区别是与积极或愉快情绪相关的食欲动机系统和与消极或不愉快情绪相关的厌恶动机系统。为了探索这两个系统的神经基础，12名健康女性观看了先前被证明能引发愉快、不愉快和中性情绪的图片，同时获得了区域脑血流的正电子发射断层扫描（PET）测量结果。愉快和不愉快的情绪与中性情绪的区别是，在内侧前额叶皮层（Brodmann's area 9）、丘脑、下丘脑和中脑附近的脑血流量显著增加（P < 0.005）。通过激活双侧枕颞叶皮层、小脑、左侧海马旁回、海马和杏仁核来区分不愉快情绪与中性或愉快情绪（P < 0.005）。通过激活左尾状核头部，愉快情绪与中性情绪区别开来（P < 0.005）。这些发现与最近其他关于人类情绪的PET研究的结果一致，并表明在健康女性中，调节愉快和不愉快情绪的神经网络既有共同的成分，也有独特的成分。1997爱思唯尔科学有限公司
Substantial evidence suggests that a key distinction in the classification of human emotion is that between an appetitive motivational system associated with positive or pleasant emotion and an aversive motivational system associated with negative or unpleasant emotion. To explore the neural substrates of these two systems, 12 healthy women viewed sets of pictures previously demonstrated to elicit pleasant, unpleasant and neutral emotion, while positron emission tomographic (PET) measurements of regional cerebral blood flow were obtained. Pleasant and unpleasant emotions were each distinguished from neutral emotion conditions by significantly increased cerebral blood flow in the vicinity of the medial prefrontal cortex (Brodmann's area 9), thalamus, hypothalamus and midbrain (P < 0.005). Unpleasant was distinguished from neutral or pleasant emotion by activation of the bilateral occipito temporal cortex and cerebellum, and left parahippocampal gyrus, hippocampus and amygdala (P < 0.005). Pleasant was also distinguished from neutral but not unpleasant emotion by activation of the head of the left caudate nucleus (P < 0.005). These findings are consistent with those from other recent PET studies of human emotion and demonstrate that there are both common and unique components of the neural networks mediating pleasant and unpleasant emotion in healthy women. (C) 1997 Elsevier Science Ltd.